245709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 779521..780178 Replicon chromosome
Accession NZ_CP097646
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag M8232_RS03840 Protein ID WP_004205323.1
Coordinates 779768..780178 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M8232_RS03835 Protein ID WP_002916312.1
Coordinates 779521..779787 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS03810 (774729) 774729..776162 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
M8232_RS03815 (776281) 776281..777009 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
M8232_RS03820 (777060) 777060..777371 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M8232_RS03825 (777534) 777534..778193 + 660 WP_004205319.1 hemolysin III family protein -
M8232_RS03830 (778292) 778292..779275 - 984 WP_048295573.1 tRNA-modifying protein YgfZ -
M8232_RS03835 (779521) 779521..779787 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M8232_RS03840 (779768) 779768..780178 + 411 WP_004205323.1 protein YgfX Toxin
M8232_RS03845 (780185) 780185..780706 - 522 WP_004205324.1 flavodoxin FldB -
M8232_RS03850 (780807) 780807..781703 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M8232_RS03855 (781726) 781726..782439 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M8232_RS03860 (782445) 782445..784178 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T245709 WP_004205323.1 NZ_CP097646:779768-780178 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245709 WP_002916312.1 NZ_CP097646:779521-779787 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References