Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3190029..3191772 Replicon chromosome
Accession NZ_CP097636
Organism Aquincola tertiaricarbonis strain RN12

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MW290_RS29105 Protein ID WP_250197835.1
Coordinates 3190906..3191772 (-) Length 289 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MW290_RS29100 Protein ID WP_250197834.1
Coordinates 3190029..3190877 (-) Length 283 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW290_RS29080 (MW290_29075) 3185190..3186665 - 1476 WP_250197830.1 aldehyde dehydrogenase -
MW290_RS29085 (MW290_29080) 3186685..3187491 - 807 WP_250197831.1 aspartate dehydrogenase -
MW290_RS29090 (MW290_29085) 3187498..3189192 - 1695 WP_250197832.1 thiamine pyrophosphate-binding protein -
MW290_RS29095 (MW290_29090) 3189185..3190009 - 825 WP_250197833.1 SDR family oxidoreductase -
MW290_RS29100 (MW290_29095) 3190029..3190877 - 849 WP_250197834.1 IclR family transcriptional regulator Antitoxin
MW290_RS29105 (MW290_29100) 3190906..3191772 - 867 WP_250197835.1 alpha/beta fold hydrolase Toxin
MW290_RS29110 (MW290_29105) 3191781..3192326 - 546 WP_250197836.1 cupin domain-containing protein -
MW290_RS29115 (MW290_29110) 3192336..3193151 - 816 WP_250197837.1 SDR family oxidoreductase -
MW290_RS29120 (MW290_29115) 3193162..3193938 - 777 WP_250197838.1 ABC transporter permease -
MW290_RS29125 (MW290_29120) 3193952..3194917 - 966 WP_250200131.1 ABC transporter substrate-binding protein -
MW290_RS29130 (MW290_29125) 3194985..3195767 - 783 WP_250197839.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-277)

Antitoxin

ArsR-like helix-turn-helix domain

(25-94)


Sequences

Toxin        


Download         Length: 289 a.a.        Molecular weight: 29744.30 Da        Isoelectric Point: 6.5952

>T245707 WP_250197835.1 NZ_CP097636:c3191772-3190906 [Aquincola tertiaricarbonis]
MSPDLQLPAADLADLDARFGVQRIAVGGGRVVAVRRMGQGLPVVCLHGIGSGSASWVEVAPLIAPQAELIAWDAPGYGDS
TPLPMAEPRATDYAQRLAELLDALHIHRCVLVGHSLGALTAAAAAQPGGPLAGRIAQLLLISPARGYGAPDRAAQGAQVQ
AERLATLAELGIEGTARLRSGRLLSAHAPEAARLRVRWNMARLNEHGYRQAVALLCGDDLLAYLPPAVPVQVAVGELDVI
TPPAACAEVAAACGVPLQPIAQAGHASYVERPEAVSALLATCLDKAAR

Download         Length: 867 bp

Antitoxin


Download         Length: 283 a.a.        Molecular weight: 30867.32 Da        Isoelectric Point: 6.1495

>AT245707 WP_250197834.1 NZ_CP097636:c3190877-3190029 [Aquincola tertiaricarbonis]
MSTPDAELADDGQDRYIVPALERGLRILGEFSRENRTLGAPELARRFGLPRSTVFRLLATLESMGFIEKTEGGREYRLGL
AVLRLGFEYLASLELTELGLPILNRLSEAIGYPCNLVVRDGRSIVYVAKVTTPTPFASSVTVGTRLPAHATVLGRVLLED
LTLPELRAMYPEDRLEIFSPSTPRTVIELFNLVQADRERGHVQGEGFFESNISTIAAPVRDHSGRVVAALGATITSAHID
GERMDEMVRRVRDAAQELSALLNYAPASASRNVVPLRGGKPA

Download         Length: 849 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References