Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2105092..2106718 Replicon chromosome
Accession NZ_CP097635
Organism Aquincola tertiaricarbonis strain RN12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MW290_RS09660 Protein ID WP_250194456.1
Coordinates 2105092..2106447 (-) Length 452 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MW290_RS09665 Protein ID WP_250194457.1
Coordinates 2106452..2106718 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW290_RS09645 (MW290_09645) 2100438..2102120 - 1683 WP_250194453.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
MW290_RS09650 (MW290_09650) 2102290..2103045 - 756 WP_250194454.1 response regulator transcription factor -
MW290_RS09655 (MW290_09655) 2103030..2104916 - 1887 WP_250194455.1 ATP-binding protein -
MW290_RS09660 (MW290_09660) 2105092..2106447 - 1356 WP_250194456.1 type II toxin-antitoxin system HipA family toxin Toxin
MW290_RS09665 (MW290_09665) 2106452..2106718 - 267 WP_250194457.1 helix-turn-helix transcriptional regulator Antitoxin
MW290_RS09670 (MW290_09670) 2106778..2107935 - 1158 WP_250194458.1 alanine racemase -
MW290_RS09675 (MW290_09675) 2107928..2109214 - 1287 WP_259373438.1 D-amino acid dehydrogenase -
MW290_RS09680 (MW290_09680) 2109402..2110940 + 1539 WP_250194460.1 sigma 54-interacting transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-66)


Sequences

Toxin        


Download         Length: 452 a.a.        Molecular weight: 49507.72 Da        Isoelectric Point: 8.9830

>T245704 WP_250194456.1 NZ_CP097635:c2106447-2105092 [Aquincola tertiaricarbonis]
MGRLSHHRTLGLWMNGERVGRWTLAPSAPDLLQYDPAWLQSEAGRPLSLSLPFLPGNAPHRGPAVRAYFENLLPDSRDIR
ERLARRFGVGSTSAFDLLAEIGRDCVGALEILPDDQSSNGVAPVKAEPLTEAQVAQLLRSATTPQALGRGTDDEDFRISI
AGAQEKTALLWHGGQWCLPRGSTPTSHILKLPLGLVGGMRLDLRDSVENEWLCALILKAFGLPVATCHPLQFEDVKVLGI
ERFDRSWRSPPRGAQRLLRLPQEDLCQATGVPPEAKYEADGGPGMDRILGVLDGSTERAQDRRHFFQAQLLFWMLCATDG
HAKNFSLFLRPGGRYQLTPLYDVLSAYPVLGDGPARISAHRARMAMAVRSKNAHWRMRDIHRRHWVALGMRHGITTEDGR
GVEALIDELVARTPAVIAAVQGQLPAWFPQRVAASIFSGLAGAARRLGAAA

Download         Length: 1356 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9771.27 Da        Isoelectric Point: 7.2026

>AT245704 WP_250194457.1 NZ_CP097635:c2106718-2106452 [Aquincola tertiaricarbonis]
MQKFHLRTADQLPALLQAFRKQAGLTQREVALRLGVTQQTYSALERNADTVGAARLLKLLHILGVEWVLTQPDPDAEAPL
SVAETPPW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References