245703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1567974..1569712 Replicon chromosome
Accession NZ_CP097635
Organism Aquincola tertiaricarbonis strain RN12

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag MW290_RS07255 Protein ID WP_250194010.1
Coordinates 1569059..1569712 (-) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag MW290_RS07250 Protein ID WP_250194009.1
Coordinates 1567974..1569059 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW290_RS07225 (MW290_07225) 1563394..1563819 + 426 WP_250194004.1 oxalurate catabolism protein HpxZ -
MW290_RS07230 (MW290_07230) 1563830..1564585 + 756 WP_250194005.1 GntR family transcriptional regulator -
MW290_RS07235 (MW290_07235) 1564590..1565057 - 468 WP_250194006.1 PaaI family thioesterase -
MW290_RS07240 (MW290_07240) 1565213..1566298 + 1086 WP_250194007.1 phosphotransferase -
MW290_RS07245 (MW290_07245) 1566301..1567977 + 1677 WP_250194008.1 long-chain fatty acid--CoA ligase -
MW290_RS07250 (MW290_07250) 1567974..1569059 - 1086 WP_250194009.1 macro domain-containing protein Antitoxin
MW290_RS07255 (MW290_07255) 1569059..1569712 - 654 WP_250194010.1 DUF4433 domain-containing protein Toxin
MW290_RS07260 (MW290_07260) 1569800..1570864 + 1065 WP_250194011.1 Gfo/Idh/MocA family oxidoreductase -
MW290_RS07265 (MW290_07265) 1571034..1571624 + 591 WP_250194012.1 lipocalin family protein -
MW290_RS07270 (MW290_07270) 1571665..1572720 - 1056 WP_250194013.1 hypothetical protein -
MW290_RS07275 (MW290_07275) 1572981..1573793 + 813 WP_250194014.1 ABC transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 24669.24 Da        Isoelectric Point: 8.6999

>T245703 WP_250194010.1 NZ_CP097635:c1569712-1569059 [Aquincola tertiaricarbonis]
MATDYANLLNPERARIFRIIHRSNLPWVLEHGLHCGNSATRSPQWVSIGNQELIAKRASWPVRAGAGGVLNDYVPFYFTP
FSPMMLAIRTGWNGVQQHRPQDILILVSDLHRISALGLTWLFTDTHANNGVVRYFQRVEDLAQLDWRILQQRDFRRDPDD
PGKFGRYQAEVLVHRQVPLQGLSGIVCADDDGKMLVEQAVAAACKQLQVVTRPGWYL

Download         Length: 654 bp

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 40129.21 Da        Isoelectric Point: 7.4779

>AT245703 WP_250194009.1 NZ_CP097635:c1569059-1567974 [Aquincola tertiaricarbonis]
MISYTQGNLLEARVDALVNTVNTVGVMGKGIALMFKERFERNFKLYAAACKAGEVQVGRMFVTETDELEAPRWIINFPTK
DHWRNPSRLEWVEAGLVDLKRVLKELNIRSVAIPPLGAGNGGLDWGVVKACIHKALADLDGVEVVVYEPTGRYQNVAKRS
GVQALTPARALVAEAIRRYWVLGMECSLLEVQKLAWFIERSLNHLGLRNDLKLNFRAHRYGPFATHLNHLLDSLDGSYLK
SDKRIADAAPLDVIAFNEDRQEVVQAYLKSEGKEVAPALELVSRVISGFESPFGMELLASVDWLISREGVAPEVPALLHG
LAHWPADQAGGAGRRKQQIFDERAVQIALDQLRRSPLYAAA

Download         Length: 1086 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References