Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 603..1077 Replicon plasmid p4_140253
Accession NZ_CP097631
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag M9P58_RS29445 Protein ID WP_004197762.1
Coordinates 603..869 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag M9P58_RS29450 Protein ID WP_000879771.1
Coordinates 853..1077 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS29440 (M9P58_29440) 183..533 + 351 WP_004197756.1 hypothetical protein -
M9P58_RS29445 (M9P58_29445) 603..869 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9P58_RS29450 (M9P58_29450) 853..1077 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
M9P58_RS29455 (M9P58_29455) 1744..1956 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
M9P58_RS29460 (M9P58_29460) 1963..2472 - 510 WP_032433972.1 MbeB family mobilization protein -
M9P58_RS29465 (M9P58_29465) 2507..2941 - 435 Protein_6 relaxase/mobilization nuclease domain-containing protein -
M9P58_RS29470 (M9P58_29470) 3150..3494 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
M9P58_RS29475 (M9P58_29475) 3484..3660 - 177 WP_004197757.1 hypothetical protein -
M9P58_RS29480 (M9P58_29480) 4815..5141 + 327 WP_050516389.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5595 5595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T245700 WP_004197762.1 NZ_CP097631:c869-603 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT245700 WP_000879771.1 NZ_CP097631:c1077-853 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References