Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 7015..7595 Replicon plasmid p3_140253
Accession NZ_CP097630
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag M9P58_RS29410 Protein ID WP_071177730.1
Coordinates 7281..7595 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag M9P58_RS29405 Protein ID WP_000093040.1
Coordinates 7015..7293 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS29375 (M9P58_29375) 3075..3224 - 150 WP_032440454.1 colicin release lysis protein -
M9P58_RS29380 (M9P58_29380) 3309..3566 - 258 WP_032440455.1 colicin E3-like toxin immunity protein -
M9P58_RS29385 (M9P58_29385) 3576..5261 - 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
M9P58_RS29390 (M9P58_29390) 5588..5833 + 246 WP_032440458.1 hypothetical protein -
M9P58_RS29395 (M9P58_29395) 6107..6478 + 372 WP_001237044.1 cell envelope integrity protein TolA -
M9P58_RS29400 (M9P58_29400) 6475..6840 + 366 WP_072354022.1 TonB family protein -
M9P58_RS29405 (M9P58_29405) 7015..7293 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
M9P58_RS29410 (M9P58_29410) 7281..7595 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9P58_RS29415 (M9P58_29415) 7759..8187 + 429 WP_001140599.1 hypothetical protein -
M9P58_RS29420 (M9P58_29420) 8213..8392 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
M9P58_RS29425 (M9P58_29425) 8419..8949 - 531 WP_071177729.1 hypothetical protein -
M9P58_RS29430 (M9P58_29430) 8956..9687 - 732 WP_071177728.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T245699 WP_071177730.1 NZ_CP097630:7281-7595 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT245699 WP_000093040.1 NZ_CP097630:7015-7293 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References