Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 552850..553477 Replicon chromosome
Accession NC_013853
Organism Streptococcus mitis B6

Toxin (Protein)


Gene name parE Uniprot ID D3H7L8
Locus tag SMI_RS03095 Protein ID WP_000384973.1
Coordinates 553127..553477 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D3H7L7
Locus tag SMI_RS03090 Protein ID WP_000020412.1
Coordinates 552850..553137 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMI_RS03065 548526..549365 + 840 WP_001192120.1 carbohydrate ABC transporter permease -
SMI_RS03070 549491..549943 + 453 WP_000575438.1 YhcH/YjgK/YiaL family protein -
SMI_RS03075 549963..550607 + 645 WP_000057475.1 DUF624 domain-containing protein -
SMI_RS03080 550779..551696 + 918 WP_001281520.1 dihydrodipicolinate synthase family protein -
SMI_RS03085 551714..552610 + 897 WP_000150236.1 ROK family protein -
SMI_RS03090 552850..553137 + 288 WP_000020412.1 hypothetical protein Antitoxin
SMI_RS03095 553127..553477 + 351 WP_000384973.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SMI_RS03100 553539..554390 - 852 WP_000360347.1 MurR/RpiR family transcriptional regulator -
SMI_RS03105 554583..556640 + 2058 WP_012972469.1 penicillin-binding protein 2B -
SMI_RS03110 556651..557247 + 597 WP_000966756.1 recombination mediator RecR -
SMI_RS03115 557423..558466 + 1044 WP_000814687.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13796.94 Da        Isoelectric Point: 10.0320

>T24569 WP_000384973.1 NC_013853:553127-553477 [Streptococcus mitis B6]
MDYKRYRILYSPRVIDSLDKRYQYIAEEIGSVEAARRKVANIRKDINRLKIFPQAGFDADEKFGKKLDPHYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T24569 NC_013853:553127-553477 [Streptococcus mitis B6]
ATGGATTATAAAAGATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAAGATATCAGTATATAGCGGA
GGAAATCGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAATATTAGAAAAGATATTAATCGGCTAAAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGATCCTCACTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTTAAGACTAAGTCAAGATACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10871.28 Da        Isoelectric Point: 4.1285

>AT24569 WP_000020412.1 NC_013853:552850-553137 [Streptococcus mitis B6]
MSIANLNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT24569 NC_013853:552850-553137 [Streptococcus mitis B6]
ATGTCTATAGCAAATCTAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTGGTAAATGATGCCATGGAAGTGTTAAA
AGAACAAAATCTCTCTCTTTCATCGGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAAGAGTACTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3H7L8

Antitoxin

Source ID Structure
AlphaFold DB D3H7L7

References