Detailed information of TA system TA024569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 552850..553477
• Replicon: chromosome
• Accession: NC_013853
• Organism: Streptococcus mitis B6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D3H7L8
• Locus tag: SMI_RS03095
• Protein ID: WP_000384973.1
• Coordinates: 553127..553477 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D3H7L7
• Locus tag: SMI_RS03090
• Protein ID: WP_000020412.1
• Coordinates: 552850..553137 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMI_RS03065	548526..549365	+	840	WP_001192120.1	carbohydrate ABC transporter permease	-
SMI_RS03070	549491..549943	+	453	WP_000575438.1	YhcH/YjgK/YiaL family protein	-
SMI_RS03075	549963..550607	+	645	WP_000057475.1	DUF624 domain-containing protein	-
SMI_RS03080	550779..551696	+	918	WP_001281520.1	dihydrodipicolinate synthase family protein	-
SMI_RS03085	551714..552610	+	897	WP_000150236.1	ROK family protein	-
SMI_RS03090	552850..553137	+	288	WP_000020412.1	hypothetical protein	Antitoxin
SMI_RS03095	553127..553477	+	351	WP_000384973.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
SMI_RS03100	553539..554390	-	852	WP_000360347.1	MurR/RpiR family transcriptional regulator	-
SMI_RS03105	554583..556640	+	2058	WP_012972469.1	penicillin-binding protein 2B	-
SMI_RS03110	556651..557247	+	597	WP_000966756.1	recombination mediator RecR	-
SMI_RS03115	557423..558466	+	1044	WP_000814687.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13796.94 Da
• Isoelectric Point: 10.0320

>T24569 WP_000384973.1 NC_013853:553127-553477 [Streptococcus mitis B6]
MDYKRYRILYSPRVIDSLDKRYQYIAEEIGSVEAARRKVANIRKDINRLKIFPQAGFDADEKFGKKLDPHYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Nucleotide

• Length: 351 bp

>T24569 NC_013853:553127-553477 [Streptococcus mitis B6]
ATGGATTATAAAAGATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAAGATATCAGTATATAGCGGA
GGAAATCGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAATATTAGAAAAGATATTAATCGGCTAAAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGATCCTCACTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTTAAGACTAAGTCAAGATACGACTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10871.28 Da
• Isoelectric Point: 4.1285

>AT24569 WP_000020412.1 NC_013853:552850-553137 [Streptococcus mitis B6]
MSIANLNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Nucleotide

• Length: 288 bp

>AT24569 NC_013853:552850-553137 [Streptococcus mitis B6]
ATGTCTATAGCAAATCTAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTGGTAAATGATGCCATGGAAGTGTTAAA
AGAACAAAATCTCTCTCTTTCATCGGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAAGAGTACTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Structures

Toxin

• AlphaFold DB: D3H7L8

Antitoxin

• AlphaFold DB: D3H7L7