Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5387736..5388361 Replicon chromosome
Accession NZ_CP097626
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M9P58_RS26585 Protein ID WP_002882817.1
Coordinates 5387736..5388119 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M9P58_RS26590 Protein ID WP_004150355.1
Coordinates 5388119..5388361 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS26570 (M9P58_26570) 5385102..5386004 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M9P58_RS26575 (M9P58_26575) 5386001..5386636 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M9P58_RS26580 (M9P58_26580) 5386633..5387562 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M9P58_RS26585 (M9P58_26585) 5387736..5388119 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M9P58_RS26590 (M9P58_26590) 5388119..5388361 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M9P58_RS26595 (M9P58_26595) 5388566..5389483 + 918 WP_002882812.1 alpha/beta hydrolase -
M9P58_RS26600 (M9P58_26600) 5389497..5390438 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M9P58_RS26605 (M9P58_26605) 5390483..5390920 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M9P58_RS26610 (M9P58_26610) 5390917..5391777 - 861 WP_002882807.1 virulence factor BrkB family protein -
M9P58_RS26615 (M9P58_26615) 5391771..5392370 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T245687 WP_002882817.1 NZ_CP097626:c5388119-5387736 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT245687 WP_004150355.1 NZ_CP097626:c5388361-5388119 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References