Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4907467..4907983 Replicon chromosome
Accession NZ_CP097626
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M9P58_RS24280 Protein ID WP_002886902.1
Coordinates 4907467..4907751 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M9P58_RS24285 Protein ID WP_002886901.1
Coordinates 4907741..4907983 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS24255 (M9P58_24255) 4902951..4903214 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M9P58_RS24260 (M9P58_24260) 4903344..4903517 + 174 WP_002886906.1 hypothetical protein -
M9P58_RS24265 (M9P58_24265) 4903520..4904263 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M9P58_RS24270 (M9P58_24270) 4904620..4906758 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M9P58_RS24275 (M9P58_24275) 4906999..4907463 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M9P58_RS24280 (M9P58_24280) 4907467..4907751 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9P58_RS24285 (M9P58_24285) 4907741..4907983 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M9P58_RS24290 (M9P58_24290) 4908061..4909971 - 1911 WP_004152270.1 PRD domain-containing protein -
M9P58_RS24295 (M9P58_24295) 4909994..4911148 - 1155 WP_002886900.1 lactonase family protein -
M9P58_RS24300 (M9P58_24300) 4911214..4911954 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245685 WP_002886902.1 NZ_CP097626:c4907751-4907467 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245685 WP_002886901.1 NZ_CP097626:c4907983-4907741 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References