Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4804886..4805696 Replicon chromosome
Accession NZ_CP097626
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag M9P58_RS23800 Protein ID WP_002887280.1
Coordinates 4804886..4805419 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M9P58_RS23805 Protein ID WP_002887278.1
Coordinates 4805430..4805696 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS23795 (M9P58_23795) 4803717..4804838 + 1122 WP_002887282.1 cupin domain-containing protein -
M9P58_RS23800 (M9P58_23800) 4804886..4805419 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
M9P58_RS23805 (M9P58_23805) 4805430..4805696 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M9P58_RS23810 (M9P58_23810) 4805799..4807232 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
M9P58_RS23815 (M9P58_23815) 4807222..4807905 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M9P58_RS23820 (M9P58_23820) 4808077..4809462 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
M9P58_RS23825 (M9P58_23825) 4809480..4809824 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T245684 WP_002887280.1 NZ_CP097626:c4805419-4804886 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245684 WP_002887278.1 NZ_CP097626:c4805696-4805430 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN


Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References