Detailed information of TA system TA024568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 258619..259153
• Replicon: chromosome
• Accession: NC_013853
• Organism: Streptococcus mitis B6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D3H6P5
• Locus tag: SMI_RS01370
• Protein ID: WP_000916506.1
• Coordinates: 258875..259153 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SMI_RS01365
• Protein ID: WP_000047862.1
• Coordinates: 258619..258882 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMI_RS01360	254126..258517	+	4392	WP_000071439.1	PolC-type DNA polymerase III	-
SMI_RS01365	258619..258882	+	264	WP_000047862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SMI_RS01370	258875..259153	+	279	WP_000916506.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SMI_RS01375	259347..260588	+	1242	WP_000243934.1	aminopeptidase	-
SMI_RS01380	260598..260828	+	231	WP_000901572.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
SMI_RS01385	261052..261774	+	723	WP_001234916.1	rRNA pseudouridine synthase	-
SMI_RS01390	261885..263216	+	1332	WP_000991650.1	aminopeptidase C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	263358..264674	1316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11107.99 Da
• Isoelectric Point: 9.8355

>T24568 WP_000916506.1 NC_013853:258875-259153 [Streptococcus mitis B6]
VLKMRYHKQFKKDFKLAMKRGLKTELLEEVLNFLVQEKELPARYRDHQLTASRHFQGVRECHIQPDWLLVYKVDKEELIL
NLLRTGSHSDLF

Nucleotide

• Length: 279 bp

>T24568 NC_013853:258875-259153 [Streptococcus mitis B6]
GTGCTTAAGATGCGTTATCATAAACAGTTTAAAAAAGATTTTAAGTTGGCTATGAAGCGTGGTTTGAAGACAGAATTATT
AGAAGAAGTTTTAAATTTTCTTGTTCAAGAAAAAGAACTTCCTGCTAGATATCGTGATCATCAATTGACGGCATCCAGGC
ATTTTCAAGGAGTTCGTGAGTGCCATATCCAGCCAGATTGGCTTTTGGTTTATAAAGTAGACAAGGAAGAATTGATTTTA
AATTTGCTGAGGACAGGTAGTCATAGTGATTTGTTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10060.45 Da
• Isoelectric Point: 4.4091

>AT24568 WP_000047862.1 NC_013853:258619-258882 [Streptococcus mitis B6]
MSKTSMSIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQGLPFDVRLDENRKLLEVLTDLDKNRNMSQSFESISD
LMEDLRA

Nucleotide

• Length: 264 bp

>AT24568 NC_013853:258619-258882 [Streptococcus mitis B6]
ATGTCAAAGACGAGTATGAGCATCCGTCTGGATAGTGAAGTTAAGGAGCAGGCCCAACAGGTGTTTAGTAATCTGGGAAT
GGATATGACAACGGCTATTAATATTTTCCTTCGTCAGGCTATTCAATATCAGGGATTACCTTTTGATGTTAGACTAGACG
AAAATCGGAAGTTGCTTGAGGTATTAACGGATTTAGACAAAAATCGTAATATGAGCCAATCCTTTGAATCAATCTCTGAC
TTGATGGAGGATTTGCGTGCTTAA

Structures

Toxin

• AlphaFold DB: D3H6P5