Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741994..742769 Replicon chromosome
Accession NZ_CP097626
Organism Klebsiella pneumoniae strain 140253

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M9P58_RS03710 Protein ID WP_004150910.1
Coordinates 742284..742769 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M9P58_RS03705 Protein ID WP_004150912.1
Coordinates 741994..742287 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9P58_RS03685 (M9P58_03685) 737125..738036 + 912 WP_004188550.1 LysR family transcriptional regulator -
M9P58_RS03690 (M9P58_03690) 738037..739185 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M9P58_RS03695 (M9P58_03695) 739196..740572 - 1377 WP_004217775.1 cystathionine beta-synthase -
M9P58_RS03705 (M9P58_03705) 741994..742287 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M9P58_RS03710 (M9P58_03710) 742284..742769 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M9P58_RS03715 (M9P58_03715) 743473..744066 + 594 WP_004188553.1 hypothetical protein -
M9P58_RS03720 (M9P58_03720) 744163..744379 + 217 Protein_731 transposase -
M9P58_RS03725 (M9P58_03725) 744985..745857 + 873 WP_004188557.1 ParA family protein -
M9P58_RS03730 (M9P58_03730) 745857..746240 + 384 WP_004150906.1 hypothetical protein -
M9P58_RS03735 (M9P58_03735) 746233..747600 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 740951..744315 3364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245676 WP_004150910.1 NZ_CP097626:742284-742769 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245676 WP_004150912.1 NZ_CP097626:741994-742287 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References