245672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1572233..1573877 Replicon chromosome
Accession NZ_CP097622
Organism Pasteurella multocida strain P2723

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M8856_RS07245 Protein ID WP_250031884.1
Coordinates 1572570..1573877 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M8856_RS07240 Protein ID WP_250031885.1
Coordinates 1572233..1572568 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8856_RS07215 (M8856_07215) 1568311..1568970 + 660 WP_005724855.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8856_RS07220 (M8856_07220) 1569034..1569603 + 570 WP_064968759.1 Der GTPase-activating protein YihI -
M8856_RS07225 (M8856_07225) 1569609..1570037 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8856_RS07230 (M8856_07230) 1570061..1571428 + 1368 WP_250031888.1 oxygen-independent coproporphyrinogen III oxidase -
M8856_RS07235 (M8856_07235) 1571469..1572137 + 669 WP_250031886.1 NAD(P)H-dependent oxidoreductase -
M8856_RS07240 (M8856_07240) 1572233..1572568 - 336 WP_250031885.1 helix-turn-helix transcriptional regulator Antitoxin
M8856_RS07245 (M8856_07245) 1572570..1573877 - 1308 WP_250031884.1 HipA domain-containing protein Toxin
M8856_RS07250 (M8856_07250) 1574095..1575231 + 1137 WP_163884298.1 anhydro-N-acetylmuramic acid kinase -
M8856_RS07255 (M8856_07255) 1575297..1577879 - 2583 WP_139639146.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50540.34 Da        Isoelectric Point: 4.9147

>T245672 WP_250031884.1 NZ_CP097622:c1573877-1572570 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFEYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12548.66 Da        Isoelectric Point: 10.5259

>AT245672 WP_250031885.1 NZ_CP097622:c1572568-1572233 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKVLLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References