Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1545188..1546832 Replicon chromosome
Accession NZ_CP097620
Organism Pasteurella multocida strain P2192

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M8855_RS07120 Protein ID WP_005752891.1
Coordinates 1545525..1546832 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M8855_RS07115 Protein ID WP_005752888.1
Coordinates 1545188..1545523 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8855_RS07090 (M8855_07090) 1541265..1541924 + 660 WP_005724855.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8855_RS07095 (M8855_07095) 1541988..1542557 + 570 WP_064968759.1 Der GTPase-activating protein YihI -
M8855_RS07100 (M8855_07100) 1542563..1542991 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8855_RS07105 (M8855_07105) 1543015..1544382 + 1368 WP_016504414.1 oxygen-independent coproporphyrinogen III oxidase -
M8855_RS07110 (M8855_07110) 1544423..1545091 + 669 WP_071522853.1 NAD(P)H-dependent oxidoreductase -
M8855_RS07115 (M8855_07115) 1545188..1545523 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M8855_RS07120 (M8855_07120) 1545525..1546832 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
M8855_RS07125 (M8855_07125) 1547069..1548187 + 1119 WP_005758041.1 anhydro-N-acetylmuramic acid kinase -
M8855_RS07130 (M8855_07130) 1548253..1550835 - 2583 WP_005758039.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T245670 WP_005752891.1 NZ_CP097620:c1546832-1545525 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT245670 WP_005752888.1 NZ_CP097620:c1545523-1545188 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References