Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1609098..1610742 Replicon chromosome
Accession NZ_CP097618
Organism Pasteurella multocida strain P2095

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M8854_RS07480 Protein ID WP_005752891.1
Coordinates 1609435..1610742 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M8854_RS07475 Protein ID WP_005752888.1
Coordinates 1609098..1609433 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8854_RS07450 (M8854_07450) 1605176..1605835 + 660 WP_059245704.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8854_RS07455 (M8854_07455) 1605899..1606468 + 570 WP_010907368.1 Der GTPase-activating protein YihI -
M8854_RS07460 (M8854_07460) 1606474..1606902 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8854_RS07465 (M8854_07465) 1606926..1608293 + 1368 WP_059245703.1 oxygen-independent coproporphyrinogen III oxidase -
M8854_RS07470 (M8854_07470) 1608334..1609002 + 669 WP_014326419.1 nitroreductase family protein -
M8854_RS07475 (M8854_07475) 1609098..1609433 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M8854_RS07480 (M8854_07480) 1609435..1610742 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
M8854_RS07485 (M8854_07485) 1610979..1612097 + 1119 WP_005758041.1 anhydro-N-acetylmuramic acid kinase -
M8854_RS07490 (M8854_07490) 1612163..1614745 - 2583 WP_059245702.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T245668 WP_005752891.1 NZ_CP097618:c1610742-1609435 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT245668 WP_005752888.1 NZ_CP097618:c1609433-1609098 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References