Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1593946..1595590 Replicon chromosome
Accession NZ_CP097616
Organism Pasteurella multocida strain P1702

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M8853_RS07305 Protein ID WP_005752891.1
Coordinates 1594283..1595590 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M8853_RS07300 Protein ID WP_005752888.1
Coordinates 1593946..1594281 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8853_RS07275 (M8853_07275) 1590024..1590683 + 660 WP_064972639.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8853_RS07280 (M8853_07280) 1590747..1591316 + 570 WP_064972638.1 Der GTPase-activating protein YihI -
M8853_RS07285 (M8853_07285) 1591322..1591750 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8853_RS07290 (M8853_07290) 1591774..1593141 + 1368 WP_046333523.1 oxygen-independent coproporphyrinogen III oxidase -
M8853_RS07295 (M8853_07295) 1593182..1593850 + 669 WP_064968760.1 NAD(P)H-dependent oxidoreductase -
M8853_RS07300 (M8853_07300) 1593946..1594281 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M8853_RS07305 (M8853_07305) 1594283..1595590 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
M8853_RS07310 (M8853_07310) 1595827..1596945 + 1119 WP_014326420.1 anhydro-N-acetylmuramic acid kinase -
M8853_RS07315 (M8853_07315) 1597011..1599636 - 2626 Protein_1411 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T245665 WP_005752891.1 NZ_CP097616:c1595590-1594283 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT245665 WP_005752888.1 NZ_CP097616:c1594281-1593946 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References