Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1548505..1550149 Replicon chromosome
Accession NZ_CP097609
Organism Pasteurella multocida strain 11245

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M8849_RS07000 Protein ID WP_005752891.1
Coordinates 1548842..1550149 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M8849_RS06995 Protein ID WP_005752888.1
Coordinates 1548505..1548840 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8849_RS06970 (M8849_06970) 1544583..1545242 + 660 WP_169029413.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8849_RS06975 (M8849_06975) 1545306..1545875 + 570 WP_064968759.1 Der GTPase-activating protein YihI -
M8849_RS06980 (M8849_06980) 1545881..1546309 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8849_RS06985 (M8849_06985) 1546333..1547700 + 1368 WP_169029412.1 oxygen-independent coproporphyrinogen III oxidase -
M8849_RS06990 (M8849_06990) 1547741..1548409 + 669 WP_169029411.1 NAD(P)H-dependent oxidoreductase -
M8849_RS06995 (M8849_06995) 1548505..1548840 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M8849_RS07000 (M8849_07000) 1548842..1550149 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
M8849_RS07005 (M8849_07005) 1550368..1551504 + 1137 WP_169029467.1 anhydro-N-acetylmuramic acid kinase -
M8849_RS07010 (M8849_07010) 1551521..1553296 + 1776 WP_169029410.1 DUF4209 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T245661 WP_005752891.1 NZ_CP097609:c1550149-1548842 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT245661 WP_005752888.1 NZ_CP097609:c1548840-1548505 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References