Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2124139..2124740 Replicon chromosome
Accession NZ_CP097608
Organism Pasteurella multocida strain 11205

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M8848_RS09945 Protein ID WP_250193613.1
Coordinates 2124139..2124453 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M8848_RS09950 Protein ID WP_223131908.1
Coordinates 2124450..2124740 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8848_RS09910 (M8848_09910) 2119683..2120678 - 996 WP_250193609.1 hypothetical protein -
M8848_RS09915 (M8848_09915) 2120858..2121085 - 228 WP_250193610.1 hypothetical protein -
M8848_RS09920 (M8848_09920) 2121072..2121362 - 291 WP_250193611.1 hypothetical protein -
M8848_RS09925 (M8848_09925) 2121406..2122047 - 642 WP_250193612.1 DUF3560 domain-containing protein -
M8848_RS09940 (M8848_09940) 2123725..2123877 - 153 WP_250027738.1 hypothetical protein -
M8848_RS09945 (M8848_09945) 2124139..2124453 + 315 WP_250193613.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8848_RS09950 (M8848_09950) 2124450..2124740 + 291 WP_223131908.1 putative addiction module antidote protein Antitoxin
M8848_RS09955 (M8848_09955) 2124785..2125417 - 633 WP_250193614.1 S24 family peptidase -
M8848_RS09960 (M8848_09960) 2125556..2125762 + 207 WP_250193615.1 helix-turn-helix transcriptional regulator -
M8848_RS09965 (M8848_09965) 2125810..2126262 + 453 WP_250193616.1 hypothetical protein -
M8848_RS09970 (M8848_09970) 2126363..2127010 + 648 WP_250193789.1 phage antirepressor KilAC domain-containing protein -
M8848_RS09975 (M8848_09975) 2127007..2127819 + 813 WP_250193617.1 replication protein -
M8848_RS09980 (M8848_09980) 2127816..2128514 + 699 WP_250193618.1 replication protein P -
M8848_RS09985 (M8848_09985) 2128507..2129037 + 531 WP_250193619.1 MT-A70 family methyltransferase -
M8848_RS09990 (M8848_09990) 2129047..2129397 + 351 WP_250193620.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2099289..2164177 64888


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11837.74 Da        Isoelectric Point: 9.7597

>T245660 WP_250193613.1 NZ_CP097608:2124139-2124453 [Pasteurella multocida]
MFEIIETTVFNKWLKELKDLSAKAAILARINRAKNGNFGDHKSVGDGLYEMRIMKGAGYRVYYTQYKDVTYLLICGGDKS
TQKADIAKAKVLWEEIKQKEGVNV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10560.20 Da        Isoelectric Point: 5.7134

>AT245660 WP_223131908.1 NZ_CP097608:2124450-2124740 [Pasteurella multocida]
MSKKVELKPFDIAEHLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSYGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References