Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1570379..1572023 Replicon chromosome
Accession NZ_CP097606
Organism Pasteurella multocida strain 10957

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M8846_RS07110 Protein ID WP_005752891.1
Coordinates 1570716..1572023 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M8846_RS07105 Protein ID WP_005752888.1
Coordinates 1570379..1570714 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8846_RS07080 (M8846_07080) 1566457..1567116 + 660 WP_074866647.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M8846_RS07085 (M8846_07085) 1567180..1567749 + 570 WP_010907368.1 Der GTPase-activating protein YihI -
M8846_RS07090 (M8846_07090) 1567755..1568183 + 429 WP_005724851.1 DUF2489 domain-containing protein -
M8846_RS07095 (M8846_07095) 1568207..1569574 + 1368 WP_250191528.1 oxygen-independent coproporphyrinogen III oxidase -
M8846_RS07100 (M8846_07100) 1569615..1570283 + 669 WP_005724847.1 NAD(P)H-dependent oxidoreductase -
M8846_RS07105 (M8846_07105) 1570379..1570714 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M8846_RS07110 (M8846_07110) 1570716..1572023 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
M8846_RS07115 (M8846_07115) 1572242..1573378 + 1137 WP_284150421.1 anhydro-N-acetylmuramic acid kinase -
M8846_RS07120 (M8846_07120) 1573395..1575170 + 1776 WP_250191530.1 DUF4209 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T245657 WP_005752891.1 NZ_CP097606:c1572023-1570716 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT245657 WP_005752888.1 NZ_CP097606:c1570714-1570379 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References