Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 594247..594848 Replicon chromosome
Accession NZ_CP097604
Organism Pasteurella multocida strain 10159

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M8331_RS02730 Protein ID WP_083002329.1
Coordinates 594247..594561 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M8331_RS02735 Protein ID WP_083002326.1
Coordinates 594558..594848 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8331_RS02700 (M8331_02700) 589704..590729 - 1026 WP_083002339.1 hypothetical protein -
M8331_RS02705 (M8331_02705) 590814..591782 - 969 WP_083002337.1 reverse transcriptase family protein -
M8331_RS02710 (M8331_02710) 591757..592068 - 312 WP_083002334.1 helix-turn-helix transcriptional regulator -
M8331_RS02715 (M8331_02715) 593080..593307 - 228 WP_083002331.1 hypothetical protein -
M8331_RS02720 (M8331_02720) 593549..593758 - 210 WP_005756656.1 hypothetical protein -
M8331_RS02725 (M8331_02725) 593771..593938 + 168 WP_005756653.1 DUF1508 domain-containing protein -
M8331_RS02730 (M8331_02730) 594247..594561 + 315 WP_083002329.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8331_RS02735 (M8331_02735) 594558..594848 + 291 WP_083002326.1 putative addiction module antidote protein Antitoxin
M8331_RS02740 (M8331_02740) 594874..595713 - 840 WP_083002324.1 DNA replication protein DnaD -
M8331_RS02745 (M8331_02745) 595805..596491 - 687 WP_083002321.1 XRE family transcriptional regulator -
M8331_RS02750 (M8331_02750) 596619..596828 + 210 WP_005720263.1 helix-turn-helix transcriptional regulator -
M8331_RS02755 (M8331_02755) 596901..597329 + 429 WP_250190967.1 hypothetical protein -
M8331_RS02760 (M8331_02760) 597332..597739 - 408 WP_227718008.1 hypothetical protein -
M8331_RS02765 (M8331_02765) 597851..598081 + 231 WP_083002312.1 helix-turn-helix domain-containing protein -
M8331_RS02770 (M8331_02770) 598174..599034 + 861 WP_083002309.1 DNA replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 581648..632590 50942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11690.61 Da        Isoelectric Point: 9.9218

>T245653 WP_083002329.1 NZ_CP097604:594247-594561 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDITYLLICGGDKS
TQKANIAKAKALWEEIKQKEGVNV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10618.23 Da        Isoelectric Point: 5.1585

>AT245653 WP_083002326.1 NZ_CP097604:594558-594848 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAEKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References