245652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3014257..3015174 Replicon chromosome
Accession NZ_CP097602
Organism Bacillus velezensis strain UA0244

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M8965_RS15570 Protein ID WP_007407256.1
Coordinates 3014428..3015174 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8965_RS15565 Protein ID WP_003154807.1
Coordinates 3014257..3014427 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8965_RS15525 3009490..3011112 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
M8965_RS15530 3011125..3011496 + 372 WP_032874603.1 XkdW family protein -
M8965_RS15535 3011501..3011698 + 198 WP_032874605.1 XkdX family protein -
M8965_RS15540 3011755..3012516 + 762 WP_032874607.1 hypothetical protein -
M8965_RS15545 3012568..3012831 + 264 WP_003154815.1 hemolysin XhlA family protein -
M8965_RS15550 3012845..3013108 + 264 WP_003154813.1 phage holin -
M8965_RS15555 3013122..3014000 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
M8965_RS15560 3014035..3014160 - 126 WP_003154809.1 hypothetical protein -
M8965_RS15565 3014257..3014427 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8965_RS15570 3014428..3015174 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8965_RS15575 3015279..3016277 - 999 WP_032874611.1 inorganic phosphate transporter -
M8965_RS15580 3016290..3016907 - 618 WP_032874614.1 DUF47 domain-containing protein -
M8965_RS15585 3017193..3018509 - 1317 WP_032874616.1 amino acid permease -
M8965_RS15590 3018831..3019781 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T245652 WP_007407256.1 NZ_CP097602:c3015174-3014428 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245652 WP_003154807.1 NZ_CP097602:c3014427-3014257 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References