245650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3112258..3113175 Replicon chromosome
Accession NZ_CP097594
Organism Bacillus velezensis strain UA0182

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M8968_RS15090 Protein ID WP_007407256.1
Coordinates 3112258..3113004 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8968_RS15095 Protein ID WP_003154807.1
Coordinates 3113005..3113175 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8968_RS15070 3107651..3108601 - 951 WP_032874618.1 ring-cleaving dioxygenase -
M8968_RS15075 3108923..3110239 + 1317 WP_032874616.1 amino acid permease -
M8968_RS15080 3110525..3111142 + 618 WP_032874614.1 DUF47 domain-containing protein -
M8968_RS15085 3111155..3112153 + 999 WP_032874611.1 inorganic phosphate transporter -
M8968_RS15090 3112258..3113004 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8968_RS15095 3113005..3113175 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8968_RS15100 3113272..3113397 + 126 WP_003154809.1 hypothetical protein -
M8968_RS15105 3113432..3114310 - 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
M8968_RS15110 3114324..3114587 - 264 WP_003154813.1 phage holin -
M8968_RS15115 3114601..3114864 - 264 WP_003154815.1 hemolysin XhlA family protein -
M8968_RS15120 3114916..3115677 - 762 WP_032874607.1 hypothetical protein -
M8968_RS15125 3115734..3115931 - 198 WP_032874605.1 XkdX family protein -
M8968_RS15130 3115936..3116307 - 372 WP_032874603.1 XkdW family protein -
M8968_RS15135 3116320..3117942 - 1623 WP_032874601.1 pyocin knob domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3103983..3156767 52784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T245650 WP_007407256.1 NZ_CP097594:3112258-3113004 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245650 WP_003154807.1 NZ_CP097594:3113005-3113175 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References