245648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2237516..2238433 Replicon chromosome
Accession NZ_CP097593
Organism Bacillus velezensis strain UA0229

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M8969_RS10585 Protein ID WP_007407256.1
Coordinates 2237516..2238262 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8969_RS10590 Protein ID WP_003154807.1
Coordinates 2238263..2238433 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8969_RS10565 2232909..2233859 - 951 WP_032874618.1 ring-cleaving dioxygenase -
M8969_RS10570 2234181..2235497 + 1317 WP_032874616.1 amino acid permease -
M8969_RS10575 2235783..2236400 + 618 WP_032874614.1 DUF47 domain-containing protein -
M8969_RS10580 2236413..2237411 + 999 WP_032874611.1 inorganic phosphate transporter -
M8969_RS10585 2237516..2238262 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8969_RS10590 2238263..2238433 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8969_RS10595 2238530..2238655 + 126 WP_003154809.1 hypothetical protein -
M8969_RS10600 2238690..2239568 - 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
M8969_RS10605 2239582..2239845 - 264 WP_003154813.1 phage holin -
M8969_RS10610 2239859..2240122 - 264 WP_003154815.1 hemolysin XhlA family protein -
M8969_RS10615 2240174..2240935 - 762 WP_032874607.1 hypothetical protein -
M8969_RS10620 2240992..2241189 - 198 WP_032874605.1 XkdX family protein -
M8969_RS10625 2241194..2241565 - 372 WP_032874603.1 XkdW family protein -
M8969_RS10630 2241578..2243200 - 1623 WP_032874601.1 pyocin knob domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T245648 WP_007407256.1 NZ_CP097593:2237516-2238262 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245648 WP_003154807.1 NZ_CP097593:2238263-2238433 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References