245647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 637541..638178 Replicon chromosome
Accession NZ_CP097593
Organism Bacillus velezensis strain UA0229

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag M8969_RS03080 Protein ID WP_003156187.1
Coordinates 637828..638178 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag M8969_RS03075 Protein ID WP_003156188.1
Coordinates 637541..637822 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8969_RS03055 633906..634505 - 600 WP_032872997.1 rhomboid family intramembrane serine protease -
M8969_RS03060 634598..634963 + 366 WP_007609580.1 holo-ACP synthase -
M8969_RS03065 635128..636135 + 1008 WP_032872999.1 outer membrane lipoprotein carrier protein LolA -
M8969_RS03070 636252..637421 + 1170 WP_032873001.1 alanine racemase -
M8969_RS03075 637541..637822 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
M8969_RS03080 637828..638178 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M8969_RS03085 638296..639117 + 822 WP_003156182.1 STAS domain-containing protein -
M8969_RS03090 639122..639487 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
M8969_RS03095 639490..639891 + 402 WP_003156178.1 anti-sigma regulatory factor -
M8969_RS03100 639903..640910 + 1008 WP_007609589.1 PP2C family protein-serine/threonine phosphatase -
M8969_RS03105 640974..641303 + 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
M8969_RS03110 641300..641782 + 483 WP_007609591.1 anti-sigma B factor RsbW -
M8969_RS03115 641748..642536 + 789 WP_032873003.1 RNA polymerase sigma factor SigB -
M8969_RS03120 642536..643138 + 603 WP_007410234.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T245647 WP_003156187.1 NZ_CP097593:637828-638178 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT245647 WP_003156188.1 NZ_CP097593:637541-637822 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References