245645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 229763..230680 Replicon chromosome
Accession NZ_CP097591
Organism Bacillus velezensis strain UA0188

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M8962_RS01110 Protein ID WP_012117368.1
Coordinates 229934..230680 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8962_RS01105 Protein ID WP_003154807.1
Coordinates 229763..229933 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8962_RS01055 224897..225409 + 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -
M8962_RS01060 225522..225755 + 234 WP_012117363.1 XtmA -
M8962_RS01065 225771..226619 + 849 WP_012117364.1 hypothetical protein -
M8962_RS01070 226632..227003 + 372 WP_012117365.1 XkdW family protein -
M8962_RS01075 227008..227205 + 198 WP_012117366.1 XkdX family protein -
M8962_RS01080 227262..228023 + 762 WP_012117367.1 hypothetical protein -
M8962_RS01085 228075..228338 + 264 WP_003154815.1 hemolysin XhlA family protein -
M8962_RS01090 228352..228615 + 264 WP_003154813.1 phage holin -
M8962_RS01095 228629..229507 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8962_RS01105 229763..229933 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8962_RS01110 229934..230680 - 747 WP_012117368.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8962_RS01115 230785..231783 - 999 WP_007407255.1 inorganic phosphate transporter -
M8962_RS01120 231796..232413 - 618 WP_003154804.1 DUF47 domain-containing protein -
M8962_RS01125 232699..234015 - 1317 WP_007610842.1 amino acid permease -
M8962_RS01130 234338..235288 + 951 WP_012117369.1 ring-cleaving dioxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-239)

Antitoxin

(1-56)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29119.61 Da        Isoelectric Point: 4.7003

>T245645 WP_012117368.1 NZ_CP097591:c230680-229934 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp


Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245645 WP_003154807.1 NZ_CP097591:c229933-229763 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References