Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 379783..380700 Replicon chromosome
Accession NZ_CP097590
Organism Bacillus velezensis strain UA0195

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M8970_RS02120 Protein ID WP_007407256.1
Coordinates 379954..380700 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8970_RS02115 Protein ID WP_003154807.1
Coordinates 379783..379953 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8970_RS02075 375016..376638 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
M8970_RS02080 376651..377022 + 372 WP_032874603.1 XkdW family protein -
M8970_RS02085 377027..377224 + 198 WP_032874605.1 XkdX family protein -
M8970_RS02090 377281..378042 + 762 WP_032874607.1 hypothetical protein -
M8970_RS02095 378094..378357 + 264 WP_003154815.1 hemolysin XhlA family protein -
M8970_RS02100 378371..378634 + 264 WP_003154813.1 phage holin -
M8970_RS02105 378648..379526 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
M8970_RS02110 379561..379686 - 126 WP_003154809.1 hypothetical protein -
M8970_RS02115 379783..379953 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8970_RS02120 379954..380700 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8970_RS02125 380805..381803 - 999 WP_032874611.1 inorganic phosphate transporter -
M8970_RS02130 381816..382433 - 618 WP_032874614.1 DUF47 domain-containing protein -
M8970_RS02135 382719..384035 - 1317 WP_032874616.1 amino acid permease -
M8970_RS02140 384357..385307 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T245643 WP_007407256.1 NZ_CP097590:c380700-379954 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245643 WP_003154807.1 NZ_CP097590:c379953-379783 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References