245641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1422463..1423380 Replicon chromosome
Accession NZ_CP097589
Organism Bacillus velezensis strain UA0311

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M8966_RS06545 Protein ID WP_012117368.1
Coordinates 1422463..1423209 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8966_RS06550 Protein ID WP_003154807.1
Coordinates 1423210..1423380 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8966_RS06525 1417855..1418805 - 951 WP_012117369.1 ring-cleaving dioxygenase -
M8966_RS06530 1419128..1420444 + 1317 WP_007610842.1 amino acid permease -
M8966_RS06535 1420730..1421347 + 618 WP_003154804.1 DUF47 domain-containing protein -
M8966_RS06540 1421360..1422358 + 999 WP_007407255.1 inorganic phosphate transporter -
M8966_RS06545 1422463..1423209 + 747 WP_012117368.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8966_RS06550 1423210..1423380 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8966_RS06560 1423636..1424514 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8966_RS06565 1424528..1424791 - 264 WP_003154813.1 phage holin -
M8966_RS06570 1424805..1425068 - 264 WP_003154815.1 hemolysin XhlA family protein -
M8966_RS06575 1425120..1425881 - 762 WP_012117367.1 hypothetical protein -
M8966_RS06580 1425938..1426135 - 198 WP_012117366.1 XkdX family protein -
M8966_RS06585 1426140..1426511 - 372 WP_012117365.1 XkdW family protein -
M8966_RS06590 1426524..1427372 - 849 WP_012117364.1 hypothetical protein -
M8966_RS06595 1427388..1427621 - 234 WP_012117363.1 XtmA -
M8966_RS06600 1427734..1428246 - 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1414327..1437312 22985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29119.61 Da        Isoelectric Point: 4.7003

>T245641 WP_012117368.1 NZ_CP097589:1422463-1423209 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245641 WP_003154807.1 NZ_CP097589:1423210-1423380 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References