Detailed information of TA system TA024564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 733281..733911
• Replicon: chromosome
• Accession: NC_013851
• Organism: Allochromatium vinosum DSM 180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D3RPJ4
• Locus tag: ALVIN_RS03110
• Protein ID: WP_012969852.1
• Coordinates: 733510..733911 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D3RPJ3
• Locus tag: ALVIN_RS03105
• Protein ID: WP_012969851.1
• Coordinates: 733281..733526 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALVIN_RS03085	728533..730128	-	1596	WP_012969847.1	peptidoglycan glycosyltransferase	-
ALVIN_RS03090	730141..731334	-	1194	WP_012969848.1	o-succinylbenzoate synthase	-
ALVIN_RS03095	731331..732230	-	900	WP_012969849.1	1,4-dihydroxy-2-naphthoate octaprenyltransferase	-
ALVIN_RS03100	732273..733133	-	861	WP_043795497.1	1,4-dihydroxy-2-naphthoyl-CoA synthase	-
ALVIN_RS03105	733281..733526	+	246	WP_012969851.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ALVIN_RS03110	733510..733911	+	402	WP_012969852.1	type II toxin-antitoxin system VapC family toxin	Toxin
ALVIN_RS03115	733957..735717	-	1761	WP_012969853.1	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	-
ALVIN_RS03120	735714..737096	-	1383	WP_012969854.1	isochorismate synthase	-
ALVIN_RS03125	737216..738130	-	915	WP_012969855.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (8-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14902.22 Da
• Isoelectric Point: 6.0741

>T24564 WP_012969852.1 NC_013851:733510-733911 [Allochromatium vinosum DSM 180]
MIWMLDTNICSYVMRELPASVKACFYQVGPENLAISTVVLAELRYGAARHPTRSALYCAEIDNFISRLEVLPWTTGAAAH
YAELRTVLERQGQPIGNMDMLIAAHALAENAVLVTHNTREFERVPGLKVENWV

Nucleotide

• Length: 402 bp

>T24564 NC_013851:733510-733911 [Allochromatium vinosum DSM 180]
ATGATCTGGATGCTTGACACCAACATCTGTAGCTATGTGATGCGCGAGCTGCCCGCCAGTGTCAAAGCGTGTTTCTATCA
GGTCGGCCCGGAAAATCTCGCCATCTCCACGGTCGTGCTGGCCGAATTGCGTTATGGCGCTGCACGTCATCCGACGCGAT
CAGCGCTGTATTGCGCTGAAATCGACAATTTCATCAGCCGGCTGGAGGTTTTGCCCTGGACGACGGGAGCAGCCGCGCAT
TACGCCGAACTACGCACGGTACTGGAACGCCAGGGCCAGCCCATCGGCAACATGGACATGCTCATCGCGGCCCACGCGCT
GGCAGAGAACGCGGTGCTGGTCACGCACAACACTCGTGAGTTCGAGCGCGTGCCGGGATTGAAGGTAGAGAACTGGGTGT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9591.89 Da
• Isoelectric Point: 5.1634

>AT24564 WP_012969851.1 NC_013851:733281-733526 [Allochromatium vinosum DSM 180]
MRQTAKLFMNGRSQAVRLPAEFRFDGKEVYIERQGEAVILRPKAKDWGEFFARDPVMPSDFMLDRKDEPPQDREFFHDLD
A

Nucleotide

• Length: 246 bp

>AT24564 NC_013851:733281-733526 [Allochromatium vinosum DSM 180]
ATGCGTCAAACCGCCAAACTGTTCATGAACGGCCGCAGTCAGGCCGTGCGCCTGCCCGCCGAATTCCGCTTCGATGGCAA
GGAGGTCTACATCGAACGGCAGGGGGAGGCTGTCATCCTCAGGCCCAAGGCCAAGGATTGGGGGGAATTCTTTGCTCGCG
ATCCGGTGATGCCGTCGGATTTCATGTTGGATCGTAAAGACGAACCGCCGCAAGACCGGGAGTTTTTCCATGATCTGGAT
GCTTGA

Structures

Toxin

• AlphaFold DB: D3RPJ4

Antitoxin

• AlphaFold DB: D3RPJ3