Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 710083..711000 Replicon chromosome
Accession NZ_CP097588
Organism Bacillus velezensis strain UA0323

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M8961_RS02895 Protein ID WP_012117368.1
Coordinates 710083..710829 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8961_RS02900 Protein ID WP_003154807.1
Coordinates 710830..711000 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8961_RS02875 705475..706425 - 951 WP_012117369.1 ring-cleaving dioxygenase -
M8961_RS02880 706748..708064 + 1317 WP_007610842.1 amino acid permease -
M8961_RS02885 708350..708967 + 618 WP_003154804.1 DUF47 domain-containing protein -
M8961_RS02890 708980..709978 + 999 WP_007407255.1 inorganic phosphate transporter -
M8961_RS02895 710083..710829 + 747 WP_012117368.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8961_RS02900 710830..711000 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8961_RS02910 711256..712134 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8961_RS02915 712148..712411 - 264 WP_003154813.1 phage holin -
M8961_RS02920 712425..712688 - 264 WP_003154815.1 hemolysin XhlA family protein -
M8961_RS02925 712740..713501 - 762 WP_012117367.1 hypothetical protein -
M8961_RS02930 713558..713755 - 198 WP_012117366.1 XkdX family protein -
M8961_RS02935 713760..714131 - 372 WP_012117365.1 XkdW family protein -
M8961_RS02940 714144..714992 - 849 WP_012117364.1 hypothetical protein -
M8961_RS02945 715008..715241 - 234 WP_012117363.1 XtmA -
M8961_RS02950 715354..715866 - 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29119.61 Da        Isoelectric Point: 4.7003

>T245639 WP_012117368.1 NZ_CP097588:710083-710829 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245639 WP_003154807.1 NZ_CP097588:710830-711000 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References