Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1574546..1575463 Replicon chromosome
Accession NZ_CP097587
Organism Bacillus velezensis strain UA0276

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M8957_RS07205 Protein ID WP_012117368.1
Coordinates 1574546..1575292 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8957_RS07210 Protein ID WP_003154807.1
Coordinates 1575293..1575463 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8957_RS07185 1569938..1570888 - 951 WP_012117369.1 ring-cleaving dioxygenase -
M8957_RS07190 1571211..1572527 + 1317 WP_007610842.1 amino acid permease -
M8957_RS07195 1572813..1573430 + 618 WP_003154804.1 DUF47 domain-containing protein -
M8957_RS07200 1573443..1574441 + 999 WP_007407255.1 inorganic phosphate transporter -
M8957_RS07205 1574546..1575292 + 747 WP_012117368.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8957_RS07210 1575293..1575463 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8957_RS07220 1575719..1576597 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8957_RS07225 1576611..1576874 - 264 WP_003154813.1 phage holin -
M8957_RS07230 1576888..1577151 - 264 WP_003154815.1 hemolysin XhlA family protein -
M8957_RS07235 1577203..1577964 - 762 WP_012117367.1 hypothetical protein -
M8957_RS07240 1578021..1578218 - 198 WP_012117366.1 XkdX family protein -
M8957_RS07245 1578223..1578594 - 372 WP_012117365.1 XkdW family protein -
M8957_RS07250 1578607..1579455 - 849 WP_012117364.1 hypothetical protein -
M8957_RS07255 1579471..1579704 - 234 WP_012117363.1 XtmA -
M8957_RS07260 1579817..1580329 - 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29119.61 Da        Isoelectric Point: 4.7003

>T245638 WP_012117368.1 NZ_CP097587:1574546-1575292 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245638 WP_003154807.1 NZ_CP097587:1575293-1575463 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References