245636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2122083..2123000 Replicon chromosome
Accession NZ_CP097585
Organism Bacillus velezensis strain UA1365

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M8964_RS10900 Protein ID WP_012117368.1
Coordinates 2122254..2123000 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8964_RS10895 Protein ID WP_003154807.1
Coordinates 2122083..2122253 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8964_RS10845 2117217..2117729 + 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -
M8964_RS10850 2117842..2118075 + 234 WP_012117363.1 XtmA -
M8964_RS10855 2118091..2118939 + 849 WP_012117364.1 hypothetical protein -
M8964_RS10860 2118952..2119323 + 372 WP_012117365.1 XkdW family protein -
M8964_RS10865 2119328..2119525 + 198 WP_012117366.1 XkdX family protein -
M8964_RS10870 2119582..2120343 + 762 WP_012117367.1 hypothetical protein -
M8964_RS10875 2120395..2120658 + 264 WP_003154815.1 hemolysin XhlA family protein -
M8964_RS10880 2120672..2120935 + 264 WP_003154813.1 phage holin -
M8964_RS10885 2120949..2121827 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8964_RS10895 2122083..2122253 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8964_RS10900 2122254..2123000 - 747 WP_012117368.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8964_RS10905 2123105..2124103 - 999 WP_007407255.1 inorganic phosphate transporter -
M8964_RS10910 2124116..2124733 - 618 WP_003154804.1 DUF47 domain-containing protein -
M8964_RS10915 2125019..2126335 - 1317 WP_007610842.1 amino acid permease -
M8964_RS10920 2126658..2127608 + 951 WP_012117369.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2108151..2180287 72136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29119.61 Da        Isoelectric Point: 4.7003

>T245636 WP_012117368.1 NZ_CP097585:c2123000-2122254 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245636 WP_003154807.1 NZ_CP097585:c2122253-2122083 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References