Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1234195..1234681 Replicon chromosome
Accession NZ_CP097577
Organism Streptococcus suis strain 3112

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M8286_RS05970 Protein ID WP_105183716.1
Coordinates 1234195..1234464 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M8286_RS05975 Protein ID WP_105139407.1
Coordinates 1234454..1234681 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8286_RS05945 (M8286_05950) 1229406..1230323 - 918 WP_029171851.1 DNA-binding protein WhiA -
M8286_RS05950 (M8286_05955) 1230320..1231294 - 975 WP_024400159.1 YvcK family protein -
M8286_RS05955 (M8286_05960) 1231291..1232178 - 888 WP_275600607.1 RNase adapter RapZ -
M8286_RS05960 (M8286_05965) 1232200..1232577 - 378 WP_029171852.1 RidA family protein -
M8286_RS05965 (M8286_05970) 1232762..1234081 - 1320 WP_275600608.1 MATE family efflux transporter -
M8286_RS05970 (M8286_05975) 1234195..1234464 - 270 WP_105183716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8286_RS05975 (M8286_05980) 1234454..1234681 - 228 WP_105139407.1 DUF6290 family protein Antitoxin
M8286_RS05980 (M8286_05985) 1234953..1236299 - 1347 WP_136670237.1 asparagine--tRNA ligase -
M8286_RS05985 (M8286_05990) 1236314..1237495 - 1182 WP_275600609.1 pyridoxal phosphate-dependent aminotransferase -
M8286_RS05990 (M8286_05995) 1237492..1237989 - 498 WP_029171855.1 DUF5590 domain-containing protein -
M8286_RS05995 (M8286_06000) 1238203..1238652 + 450 WP_009909619.1 MarR family transcriptional regulator -
M8286_RS06000 (M8286_06005) 1238715..1239260 + 546 WP_002941732.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10419.46 Da        Isoelectric Point: 10.3916

>T245634 WP_105183716.1 NZ_CP097577:c1234464-1234195 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGLMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8464.54 Da        Isoelectric Point: 4.1707

>AT245634 WP_105139407.1 NZ_CP097577:c1234681-1234454 [Streptococcus suis]
MGIVSLRLNEAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References