245633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 945881..946376 Replicon chromosome
Accession NZ_CP097577
Organism Streptococcus suis strain 3112

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8F7Q7
Locus tag M8286_RS04680 Protein ID WP_024401228.1
Coordinates 946110..946376 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag M8286_RS04675 Protein ID WP_015646833.1
Coordinates 945881..946120 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8286_RS04645 (M8286_04640) 941293..941430 + 138 WP_162841163.1 hypothetical protein -
M8286_RS04650 (M8286_04645) 941443..942177 + 735 WP_275601639.1 TraX family protein -
M8286_RS04655 (M8286_04650) 942276..942416 + 141 WP_032512769.1 hypothetical protein -
M8286_RS04660 (M8286_04655) 942429..942818 + 390 WP_275601640.1 NisI/SpaI family lantibiotic immunity lipoprotein -
M8286_RS04665 (M8286_04660) 942827..943579 + 753 WP_275601641.1 ABC transporter ATP-binding protein -
M8286_RS04670 (M8286_04665) 943580..945526 + 1947 WP_275601642.1 ABC transporter permease -
M8286_RS04675 (M8286_04670) 945881..946120 + 240 WP_015646833.1 DUF6290 family protein Antitoxin
M8286_RS04680 (M8286_04675) 946110..946376 + 267 WP_024401228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8286_RS04685 (M8286_04680) 946418..947083 + 666 WP_275601708.1 response regulator transcription factor -
M8286_RS04690 (M8286_04685) 947080..948021 + 942 WP_275601643.1 sensor histidine kinase -
M8286_RS04695 (M8286_04690) 948096..949604 + 1509 WP_275601644.1 phosphomannomutase/phosphoglucomutase -
M8286_RS04700 (M8286_04695) 949674..950744 - 1071 WP_275601645.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10259.98 Da        Isoelectric Point: 10.4518

>T245633 WP_024401228.1 NZ_CP097577:946110-946376 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT245633 WP_015646833.1 NZ_CP097577:945881-946120 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8F7Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References