Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 568808..569479 Replicon chromosome
Accession NZ_CP097577
Organism Streptococcus suis strain 3112

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag M8286_RS02870 Protein ID WP_014637653.1
Coordinates 568808..568990 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M8286_RS02875 Protein ID WP_024404710.1
Coordinates 569030..569479 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8286_RS02855 (M8286_02850) 565635..566102 + 468 WP_024386304.1 SsrA-binding protein SmpB -
M8286_RS02860 (M8286_02855) 566366..567049 + 684 WP_105133780.1 hypothetical protein -
M8286_RS02865 (M8286_02860) 567051..567770 + 720 WP_275601412.1 ABC transporter ATP-binding protein -
M8286_RS02870 (M8286_02865) 568808..568990 + 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
M8286_RS02875 (M8286_02870) 569030..569479 + 450 WP_024404710.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M8286_RS02880 (M8286_02875) 569639..570682 - 1044 WP_275601704.1 alcohol dehydrogenase catalytic domain-containing protein -
M8286_RS02885 (M8286_02880) 570836..571696 + 861 WP_044781786.1 SAM-dependent methyltransferase TehB -
M8286_RS02890 (M8286_02885) 571889..573742 + 1854 WP_275601413.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T245632 WP_014637653.1 NZ_CP097577:568808-568990 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16654.66 Da        Isoelectric Point: 4.0193

>AT245632 WP_024404710.1 NZ_CP097577:569030-569479 [Streptococcus suis]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure

References