Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT_toxin-BrnA
Location 4164573..4165065 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name shpA Uniprot ID I4GAG4
Locus tag M8120_RS21030 Protein ID WP_002772034.1
Coordinates 4164573..4164851 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag M8120_RS21035 Protein ID WP_081417880.1
Coordinates 4164856..4165065 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS21000 (M8120_20805) 4159580..4160037 + 458 Protein_4164 transposase -
M8120_RS21005 (M8120_20810) 4160201..4160902 + 702 WP_190359245.1 NnrU family protein -
M8120_RS21010 (M8120_20815) 4160991..4161401 + 411 WP_265795870.1 thioredoxin family protein -
M8120_RS21015 (M8120_20820) 4161318..4162528 - 1211 Protein_4167 ISL3 family transposase -
M8120_RS21020 (M8120_20825) 4163022..4163678 + 657 WP_190359244.1 VWA domain-containing protein -
M8120_RS21025 (M8120_20830) 4163692..4164459 + 768 WP_190359243.1 PP2C family serine/threonine-protein phosphatase -
M8120_RS21030 (M8120_20835) 4164573..4164851 + 279 WP_002772034.1 BrnT family toxin Toxin
M8120_RS21035 (M8120_20840) 4164856..4165065 + 210 WP_081417880.1 BrnA antitoxin family protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4150368..4175780 25412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10835.42 Da        Isoelectric Point: 9.9743

>T245630 WP_002772034.1 NZ_CP097576:4164573-4164851 [Microcystis aeruginosa str. Chao 1910]
MKYEWDQDKSDANLEKHGLSFEDAPLVFGGKCVTFEDSRFVYGEIRYITLGKLKGRVVLIVHTPRSNKTRIISMRKANNR
EQKIYQKRLEEN

Download         Length: 279 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8117.96 Da        Isoelectric Point: 3.7178

>AT245630 WP_081417880.1 NZ_CP097576:4164856-4165065 [Microcystis aeruginosa str. Chao 1910]
MTDENIDYSDIPPLGDEFFTQETVSFSTSKQQLTIQLDQDILEWLKAQGKGYETQINYILREVMEQQQQ

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4GAG4

Antitoxin

Source ID Structure

References