Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 3162165..3162736 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name vapC Uniprot ID I4IBX6
Locus tag M8120_RS15875 Protein ID WP_002759489.1
Coordinates 3162165..3162506 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M8120_RS15880 Protein ID WP_190359069.1
Coordinates 3162503..3162736 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS15855 (M8120_15715) 3157177..3157458 - 282 WP_190359065.1 DUF6439 family protein -
M8120_RS15860 (M8120_15720) 3157531..3157932 + 402 WP_190359066.1 DUF2203 domain-containing protein -
M8120_RS15865 (M8120_15725) 3158258..3159508 - 1251 WP_190359067.1 methionine adenosyltransferase -
M8120_RS15870 (M8120_15730) 3159834..3162155 + 2322 WP_190359068.1 DNA helicase PcrA -
M8120_RS15875 (M8120_15735) 3162165..3162506 - 342 WP_002759489.1 DUF5615 family PIN-like protein Toxin
M8120_RS15880 (M8120_15740) 3162503..3162736 - 234 WP_190359069.1 DUF433 domain-containing protein Antitoxin
M8120_RS15885 (M8120_15745) 3163062..3163493 + 432 WP_045358126.1 CAAD domain-containing protein -
M8120_RS15890 (M8120_15750) 3164062..3165234 - 1173 WP_190359070.1 CBS domain-containing protein -
M8120_RS15895 (M8120_15755) 3165473..3165880 - 408 WP_242030190.1 recombinase family protein -
M8120_RS15900 (M8120_15760) 3166188..3166511 + 324 WP_002790944.1 thioredoxin -
M8120_RS15905 (M8120_15765) 3166585..3166905 + 321 WP_242030191.1 hypothetical protein -
M8120_RS15910 (M8120_15770) 3166957..3167574 + 618 WP_002746099.1 CBS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(11-66)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12508.41 Da        Isoelectric Point: 4.2544

>T245627 WP_002759489.1 NZ_CP097576:c3162506-3162165 [Microcystis aeruginosa str. Chao 1910]
MKIWIDAQLPPTLASWLSATFDLEASSLRDLSLRDAQDIEIFAAARAENAVIMTKDSDFIDLVCRLGTPPQILWLTCGNV
TNQNLRRLLTATLPDALKQLEQGTIIVEISNTP

Download         Length: 342 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8526.98 Da        Isoelectric Point: 4.4471

>AT245627 WP_190359069.1 NZ_CP097576:c3162736-3162503 [Microcystis aeruginosa str. Chao 1910]
MDSTVSLLTRITQTPGQCGGRPCIRGMRIRVKDILEMLAENVSITEILEDFPDLELADIQACLLFAARCTDFPKLTA

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4IBX6

Antitoxin

Source ID Structure

References