Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3047960..3048741 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag M8120_RS15330 Protein ID WP_052276780.1
Coordinates 3048247..3048741 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag M8120_RS15325 Protein ID WP_190359866.1
Coordinates 3047960..3048250 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS15295 (M8120_15165) 3044125..3044439 + 315 WP_190359951.1 hypothetical protein -
M8120_RS15300 (M8120_15170) 3044459..3045408 + 950 WP_265795351.1 IS630-like element ISMae26 family transposase -
M8120_RS15305 (M8120_15175) 3045482..3045982 + 501 WP_190359865.1 hypothetical protein -
M8120_RS15310 (M8120_15180) 3046242..3046490 + 249 WP_190359921.1 BrnT family toxin -
M8120_RS15315 (M8120_15185) 3046468..3046740 + 273 WP_012266237.1 hypothetical protein -
M8120_RS15320 3047397..3047519 - 123 WP_265795352.1 hypothetical protein -
M8120_RS15325 (M8120_15190) 3047960..3048250 + 291 WP_190359866.1 DUF1778 domain-containing protein Antitoxin
M8120_RS15330 (M8120_15195) 3048247..3048741 + 495 WP_052276780.1 GNAT family N-acetyltransferase Toxin
M8120_RS15335 (M8120_15200) 3048893..3049375 - 483 WP_190359867.1 hypothetical protein -
M8120_RS15340 (M8120_15205) 3049372..3049746 - 375 WP_002757633.1 nucleotidyltransferase domain-containing protein -
M8120_RS15345 (M8120_15210) 3049863..3050024 + 162 WP_265795353.1 hypothetical protein -
M8120_RS15350 (M8120_15215) 3050233..3050550 + 318 WP_002768334.1 2Fe-2S iron-sulfur cluster-binding protein -
M8120_RS15355 (M8120_15220) 3050633..3052273 - 1641 WP_190359868.1 CTP synthase -
M8120_RS15360 (M8120_15225) 3052514..3052912 + 399 WP_190359869.1 hypothetical protein -
M8120_RS15365 (M8120_15230) 3052922..3053692 - 771 WP_190359870.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3040335..3049746 9411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17620.32 Da        Isoelectric Point: 8.1215

>T245626 WP_052276780.1 NZ_CP097576:3048247-3048741 [Microcystis aeruginosa str. Chao 1910]
MNLTPPEPLASYHSITDFSCGITSLDDWLKRRAYANQASGATRTFVTCVDNRVVGYYALASGAISIQSANGKFRRNMPNP
IPVVILARLAVDTSSQGQGLGCGLFRDGALRVVKAADTIGIRGIIVHAISEEAKNFYLALGFDVSPLEPMTLMITLNDLR
ACIA

Download         Length: 495 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10996.62 Da        Isoelectric Point: 9.8088

>AT245626 WP_190359866.1 NZ_CP097576:3047960-3048250 [Microcystis aeruginosa str. Chao 1910]
MSSKTKSRTPRNTLNLRIKPEERNLIDMAAKVQGKNRTDFILEAARNAAEETLLERTIFLASPEAYAEFIALLDAPPQPN
ERLRKTMQTLAPWEKE

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References