Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2674463..2674970 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M8120_RS13440 Protein ID WP_043997958.1
Coordinates 2674701..2674970 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M8120_RS13435 Protein ID WP_190358662.1
Coordinates 2674463..2674711 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS13410 (M8120_13280) 2669572..2670213 - 642 WP_151696328.1 LON peptidase substrate-binding domain-containing protein -
M8120_RS13415 (M8120_13285) 2670976..2671932 + 957 WP_190358660.1 RNA polymerase sigma factor, RpoD/SigA family -
M8120_RS13420 (M8120_13290) 2672026..2672913 - 888 WP_190358661.1 S-methyl-5'-thioadenosine phosphorylase -
M8120_RS13425 (M8120_13295) 2672996..2673322 - 327 WP_002748322.1 urease subunit beta -
M8120_RS13430 (M8120_13300) 2673342..2673644 - 303 WP_002738360.1 urease subunit gamma -
M8120_RS13435 (M8120_13305) 2674463..2674711 - 249 WP_190358662.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M8120_RS13440 (M8120_13310) 2674701..2674970 - 270 WP_043997958.1 type II toxin-antitoxin system HicA family toxin Toxin
M8120_RS13445 (M8120_13315) 2675178..2675504 + 327 WP_190358663.1 DUF433 domain-containing protein -
M8120_RS13450 (M8120_13320) 2675508..2675849 + 342 WP_002757208.1 DUF5615 family PIN-like protein -
M8120_RS13455 (M8120_13325) 2676363..2676770 - 408 Protein_2664 formylglycine-generating enzyme family protein -
M8120_RS13460 (M8120_13330) 2676858..2677947 + 1090 Protein_2665 ISAs1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10150.69 Da        Isoelectric Point: 10.0825

>T245625 WP_043997958.1 NZ_CP097576:c2674970-2674701 [Microcystis aeruginosa str. Chao 1910]
MALSKKQRKILDQIFEQPVRSDVVWTDIESLLEALGAEISEGRRLRVWVALKGVKAVFHRPHPRRETDKGAVVSVRRFLS
EAGVENDEV

Download         Length: 270 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9250.25 Da        Isoelectric Point: 4.2207

>AT245625 WP_190358662.1 NZ_CP097576:c2674711-2674463 [Microcystis aeruginosa str. Chao 1910]
MKYKGYEAVVSFDDEAGIFYGEVANVRDVITFQGESVAELQQAFADSVEDYLAFCAERGEKPEKPFSDSFLSQPHPKLHQ
QI

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References