Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2597701..2598341 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M8120_RS13070 Protein ID WP_190357215.1
Coordinates 2597701..2598099 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S3JHM9
Locus tag M8120_RS13075 Protein ID WP_016514827.1
Coordinates 2598096..2598341 (-) Length 82 a.a.

Genomic Context

M8120_RS13030M8120_RS13035M8120_RS13040M8120_RS13050M8120_RS13055M8120_RS13060M8120_RS13080M8120_RS13095M8120_RS13045M8120_RS13065M8120_RS13070M8120_RS13075M8120_RS13085M8120_RS13090M8120_RS13105
Location: 2593716..2594129 (414 bp)
Type: Others
Protein ID: WP_190357212.1
Location: 2594401..2594631 (231 bp)
Type: Others
Protein ID: WP_002779924.1
Location: 2594635..2594958 (324 bp)
Type: Others
Protein ID: WP_190357213.1
Location: 2596210..2596356 (147 bp)
Type: Others
Protein ID: WP_002738886.1
Location: 2596547..2596792 (246 bp)
Type: Others
Protein ID: WP_002770883.1
Location: 2596789..2597274 (486 bp)
Type: Others
Protein ID: WP_190357214.1
Location: 2598693..2599172 (480 bp)
Type: Others
Protein ID: WP_002738680.1
Location: 2601299..2601847 (549 bp)
Type: Others
Protein ID: WP_190357217.1
Location: 2594935..2595999 (1065 bp)
Type: Others
Protein ID: Protein_2584
Location: 2597300..2597548 (249 bp)
Type: Others
Protein ID: WP_242030029.1
Location: 2597701..2598099 (399 bp)
Type: Toxin
Protein ID: WP_190357215.1
Location: 2598096..2598341 (246 bp)
Type: Antitoxin
Protein ID: WP_016514827.1
Location: 2599300..2600457 (1158 bp)
Type: Others
Protein ID: WP_190357216.1
Location: 2600525..2600884 (360 bp)
Type: Others
Protein ID: WP_002763426.1
Location: 2602232..2602423 (192 bp)
Type: Others
Protein ID: WP_045356121.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M8120_RS13030 (M8120_12900)2593716..2594129+414WP_190357212.1hypothetical protein-
M8120_RS13035 (M8120_12905)2594401..2594631+231WP_002779924.1DUF433 domain-containing protein-
M8120_RS13040 (M8120_12910)2594635..2594958+324WP_190357213.1DUF5615 family PIN-like protein-
M8120_RS13045 (M8120_12915)2594935..2595999-1065Protein_2584IS4 family transposase-
M8120_RS13050 (M8120_12920)2596210..2596356+147WP_002738886.1PEP-CTERM sorting domain-containing protein-
M8120_RS13055 (M8120_12925)2596547..2596792+246WP_002770883.1UPF0175 family protein-
M8120_RS13060 (M8120_12930)2596789..2597274+486WP_190357214.1DUF3368 domain-containing protein-
M8120_RS13065 (M8120_12935)2597300..2597548-249WP_242030029.1hypothetical protein-
M8120_RS13070 (M8120_12940)2597701..2598099-399WP_190357215.1type II toxin-antitoxin system VapC family toxinToxin
M8120_RS13075 (M8120_12945)2598096..2598341-246WP_016514827.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
M8120_RS13080 (M8120_12950)2598693..2599172+480WP_002738680.1type II toxin-antitoxin system VapC family toxin-
M8120_RS13085 (M8120_12955)2599300..2600457-1158WP_190357216.18-amino-7-oxononanoate synthase-
M8120_RS13090 (M8120_12960)2600525..2600884-360WP_002763426.1DUF6464 family protein-
M8120_RS13095 (M8120_12965)2601299..2601847+549WP_190357217.1RDD family protein-
M8120_RS13105 (M8120_12975)2602232..2602423-192WP_045356121.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15000.09 Da        Isoelectric Point: 4.5069

>T245624 WP_190357215.1 NZ_CP097576:c2598099-2597701 [Microcystis aeruginosa str. Chao 1910]
VRLLLDTQCWLWWFVQPDKLSENVIEQIANESNEVWFSVASVWEMGIKVSIGKLPLPEQIDNYVSTRMTQLGARSLEINA
SHALRAAALPLHHRDPFDRMLIAQAQVEDMTLVSADSTFNQYEVSLLWAASS

Download         Length: 399 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8858.15 Da        Isoelectric Point: 5.0190

>AT245624 WP_016514827.1 NZ_CP097576:c2598341-2598096 [Microcystis aeruginosa str. Chao 1910]
METVNIHQAKTNLSRLLSRVELGEVIVISNRGIPIAKLVPFRTSLDRRSSLGQDRGMLTIPDDFNAPLPEDILGAFEGGA
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3N0W8U9

References