Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1840828..1841418 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name PumA Uniprot ID I4GZP8
Locus tag M8120_RS09240 Protein ID WP_002786284.1
Coordinates 1840828..1841118 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M8120_RS09245 Protein ID WP_190359454.1
Coordinates 1841128..1841418 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS09220 (M8120_09125) 1836002..1836871 + 870 WP_190359452.1 bile acid:sodium symporter family protein -
M8120_RS09225 (M8120_09130) 1837601..1839490 + 1890 WP_190359453.1 ABC-F family ATP-binding cassette domain-containing protein -
M8120_RS09230 (M8120_09135) 1839687..1840048 - 362 Protein_1829 IS4 family transposase -
M8120_RS09235 (M8120_09140) 1840398..1840808 + 411 Protein_1830 hypothetical protein -
M8120_RS09240 (M8120_09145) 1840828..1841118 + 291 WP_002786284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8120_RS09245 (M8120_09150) 1841128..1841418 + 291 WP_190359454.1 putative addiction module antidote protein Antitoxin
M8120_RS09250 (M8120_09155) 1841431..1842507 - 1077 WP_242030231.1 CHAT domain-containing protein -
M8120_RS09255 (M8120_09160) 1842711..1843802 + 1092 WP_265795848.1 ISAs1 family transposase -
M8120_RS09260 (M8120_09165) 1844253..1846409 - 2157 Protein_1835 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1839687..1843802 4115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10921.57 Da        Isoelectric Point: 10.6201

>T245621 WP_002786284.1 NZ_CP097576:1840828-1841118 [Microcystis aeruginosa str. Chao 1910]
MIEIRQTKTYSEWFSGLRDRQAKARIDIRIRRLSTGNPGDVKPVGQGVSELRVDYGPGYRVYFIQQGKTLIILLAGGDKK
TQERDIKTALDLARNL

Download         Length: 291 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10233.72 Da        Isoelectric Point: 4.1074

>AT245621 WP_190359454.1 NZ_CP097576:1841128-1841418 [Microcystis aeruginosa str. Chao 1910]
MATIQTYPWDAADHLQTKEDIAAYLEAALEDGDPSLIIAALGDIARAKGITNIASETGLGSENLCKALLSEGNPEFTTVI
RILQVLGLRLQIVPIT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4GZP8

Antitoxin

Source ID Structure

References