Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1432721..1433292 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G9JKW3
Locus tag M8120_RS07230 Protein ID WP_043995641.1
Coordinates 1432960..1433292 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I4FQ39
Locus tag M8120_RS07225 Protein ID WP_002760402.1
Coordinates 1432721..1432963 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS07200 (M8120_07110) 1427829..1428254 + 426 WP_265795731.1 hypothetical protein -
M8120_RS07205 (M8120_07115) 1428786..1429247 - 462 WP_190357869.1 hypothetical protein -
M8120_RS07210 (M8120_07120) 1429759..1430727 - 969 WP_190357868.1 helix-turn-helix domain-containing protein -
M8120_RS07215 (M8120_07125) 1431158..1431820 + 663 WP_190357867.1 potassium channel family protein -
M8120_RS07220 (M8120_07130) 1431853..1432629 + 777 WP_190357866.1 DUF2092 domain-containing protein -
M8120_RS07225 (M8120_07135) 1432721..1432963 + 243 WP_002760402.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M8120_RS07230 (M8120_07140) 1432960..1433292 + 333 WP_043995641.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8120_RS07235 (M8120_07145) 1433475..1434368 + 894 WP_190357865.1 DUF6515 family protein -
M8120_RS07240 (M8120_07150) 1434365..1437427 - 3063 WP_190357864.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-108)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12588.65 Da        Isoelectric Point: 9.7817

>T245620 WP_043995641.1 NZ_CP097576:1432960-1433292 [Microcystis aeruginosa str. Chao 1910]
VTYIPERGDFLRLSFDPQIGHEQMGNRPALVVSHIDFNRKIGFAFVCPVSNTQRQNPFYVKIPDGEAVTGVIMVDQLRSL
DFRARKASFIGKCPEQLLQDVLRRIKPILF

Download         Length: 333 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8956.30 Da        Isoelectric Point: 4.0460

>AT245620 WP_002760402.1 NZ_CP097576:1432721-1432963 [Microcystis aeruginosa str. Chao 1910]
MKSQIGRWGNSLAIRIPKYAVEALNLNPKDVVECSVENGKLVIELIQALPELSLEELLAEVVESPEPEVDWGRPMGEEVW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9JKW3

Antitoxin

Source ID Structure
AlphaFold DB I4FQ39

References