245616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5174342..5175850 Replicon chromosome
Accession NZ_CP097575
Organism Pseudomonas aeruginosa strain UNC_PaerCF25

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag M9A05_RS23810 Protein ID WP_003119682.1
Coordinates 5174342..5174929 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M9A05_RS23815 Protein ID WP_250177553.1
Coordinates 5174996..5175850 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9A05_RS23805 (M9A05_23805) 5170597..5174076 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M9A05_RS23810 (M9A05_23810) 5174342..5174929 + 588 WP_003119682.1 GNAT family protein Toxin
M9A05_RS23815 (M9A05_23815) 5174996..5175850 + 855 WP_250177553.1 AraC family transcriptional regulator Antitoxin
M9A05_RS23820 (M9A05_23820) 5175947..5178112 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
M9A05_RS23825 (M9A05_23825) 5178287..5180161 + 1875 WP_250177554.1 MFS transporter -
M9A05_RS23830 (M9A05_23830) 5180222..5180431 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T245616 WP_003119682.1 NZ_CP097575:5174342-5174929 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31885.16 Da        Isoelectric Point: 7.5295

>AT245616 WP_250177553.1 NZ_CP097575:5174996-5175850 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQESLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References