Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2929909..2930414 Replicon chromosome
Accession NZ_CP097575
Organism Pseudomonas aeruginosa strain UNC_PaerCF25

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M9A05_RS13520 Protein ID WP_003083773.1
Coordinates 2930133..2930414 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M9A05_RS13515 Protein ID WP_003083775.1
Coordinates 2929909..2930136 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9A05_RS13490 (M9A05_13490) 2924927..2926420 + 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
M9A05_RS13495 (M9A05_13495) 2926589..2928016 + 1428 WP_003083784.1 GABA permease -
M9A05_RS13500 (M9A05_13500) 2928098..2928439 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M9A05_RS13505 (M9A05_13505) 2928512..2929012 - 501 WP_003101228.1 LEA type 2 family protein -
M9A05_RS13510 (M9A05_13510) 2929113..2929733 + 621 WP_003101226.1 hypothetical protein -
M9A05_RS13515 (M9A05_13515) 2929909..2930136 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M9A05_RS13520 (M9A05_13520) 2930133..2930414 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M9A05_RS13525 (M9A05_13525) 2930714..2931622 + 909 WP_016561475.1 LysR family transcriptional regulator -
M9A05_RS13530 (M9A05_13530) 2931654..2932064 - 411 WP_003101225.1 aegerolysin family protein -
M9A05_RS13535 (M9A05_13535) 2932260..2932979 - 720 Protein_2680 GntR family transcriptional regulator -
M9A05_RS13540 (M9A05_13540) 2933080..2933766 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M9A05_RS13545 (M9A05_13545) 2933815..2935164 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245615 WP_003083773.1 NZ_CP097575:2930133-2930414 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245615 WP_003083775.1 NZ_CP097575:2929909-2930136 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References