245613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1816995..1817603 Replicon chromosome
Accession NZ_CP097575
Organism Pseudomonas aeruginosa strain UNC_PaerCF25

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag M9A05_RS08355 Protein ID WP_003114156.1
Coordinates 1816995..1817342 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag M9A05_RS08360 Protein ID WP_003114155.1
Coordinates 1817352..1817603 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9A05_RS08325 (M9A05_08325) 1812416..1812628 + 213 WP_003098360.1 cysteine-rich CWC family protein -
M9A05_RS08330 (M9A05_08330) 1812628..1813320 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
M9A05_RS08335 (M9A05_08335) 1813456..1814499 + 1044 WP_003098363.1 L,D-transpeptidase -
M9A05_RS08340 (M9A05_08340) 1814579..1815316 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
M9A05_RS08345 (M9A05_08345) 1815768..1816670 + 903 WP_003098365.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
M9A05_RS08355 (M9A05_08355) 1816995..1817342 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9A05_RS08360 (M9A05_08360) 1817352..1817603 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M9A05_RS08365 (M9A05_08365) 1817817..1818800 - 984 WP_250177694.1 tyrosine-type recombinase/integrase -
M9A05_RS08370 (M9A05_08370) 1818800..1820092 - 1293 WP_003115206.1 hypothetical protein -
M9A05_RS08375 (M9A05_08375) 1820322..1821596 - 1275 WP_250177695.1 zonular occludens toxin family protein -
M9A05_RS08380 (M9A05_08380) 1821600..1821956 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 1816995..1839725 22730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T245613 WP_003114156.1 NZ_CP097575:c1817342-1816995 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT245613 WP_003114155.1 NZ_CP097575:c1817603-1817352 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References