Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1427391..1428649 Replicon chromosome
Accession NZ_CP097575
Organism Pseudomonas aeruginosa strain UNC_PaerCF25

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag M9A05_RS06555 Protein ID WP_003112528.1
Coordinates 1427391..1428146 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M9A05_RS06560 Protein ID WP_003086329.1
Coordinates 1428281..1428649 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9A05_RS06545 (M9A05_06545) 1422564..1425107 + 2544 WP_250177674.1 acyl-homoserine-lactone acylase QuiP -
M9A05_RS06550 (M9A05_06550) 1425262..1426623 - 1362 WP_003134034.1 DNA recombination protein RmuC -
M9A05_RS06555 (M9A05_06555) 1427391..1428146 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
M9A05_RS06560 (M9A05_06560) 1428281..1428649 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M9A05_RS06565 (M9A05_06565) 1428722..1430008 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
M9A05_RS06570 (M9A05_06570) 1430064..1431557 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M9A05_RS06575 (M9A05_06575) 1431732..1432208 + 477 WP_003112531.1 hypothetical protein -
M9A05_RS06580 (M9A05_06580) 1432211..1432486 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T245612 WP_003112528.1 NZ_CP097575:c1428146-1427391 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245612 WP_003086329.1 NZ_CP097575:c1428649-1428281 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References