Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 525957..527177 | Replicon | chromosome |
| Accession | NZ_CP097575 | ||
| Organism | Pseudomonas aeruginosa strain UNC_PaerCF25 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | M9A05_RS02315 | Protein ID | WP_003160088.1 |
| Coordinates | 526599..527177 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | M9A05_RS02310 | Protein ID | WP_003088112.1 |
| Coordinates | 525957..526511 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M9A05_RS02285 (M9A05_02285) | 521525..522076 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| M9A05_RS02290 (M9A05_02290) | 522073..522471 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| M9A05_RS02295 (M9A05_02295) | 522484..522807 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| M9A05_RS02300 (M9A05_02300) | 523138..523599 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| M9A05_RS02305 (M9A05_02305) | 523604..525799 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| M9A05_RS02310 (M9A05_02310) | 525957..526511 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| M9A05_RS02315 (M9A05_02315) | 526599..527177 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
| M9A05_RS02320 (M9A05_02320) | 527286..528473 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| M9A05_RS02325 (M9A05_02325) | 528463..530634 | - | 2172 | WP_009876279.1 | type I secretion system permease/ATPase | - |
| M9A05_RS02330 (M9A05_02330) | 530624..531901 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T245611 WP_003160088.1 NZ_CP097575:526599-527177 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT245611 WP_003088112.1 NZ_CP097575:525957-526511 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|