Detailed information of TA system TA024561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 295781..296414
• Replicon: chromosome
• Accession: NC_013851
• Organism: Allochromatium vinosum DSM 180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D3RMF5
• Locus tag: ALVIN_RS01250
• Protein ID: WP_012969489.1
• Coordinates: 295781..296194 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D3RMF6
• Locus tag: ALVIN_RS01255
• Protein ID: WP_012969490.1
• Coordinates: 296181..296414 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALVIN_RS01235	291811..293784	-	1974	WP_012969486.1	alpha-glucosidase C-terminal domain-containing protein	-
ALVIN_RS01240	293818..294579	-	762	WP_012969487.1	hypothetical protein	-
ALVIN_RS01245	294557..295738	-	1182	WP_148217537.1	ATP-binding protein	-
ALVIN_RS01250	295781..296194	-	414	WP_012969489.1	PIN domain-containing protein	Toxin
ALVIN_RS01255	296181..296414	-	234	WP_012969490.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ALVIN_RS01260	296506..297426	-	921	WP_012969491.1	carbohydrate kinase	-
ALVIN_RS01265	297441..298277	-	837	WP_012969492.1	HAD-IIB family hydrolase	-
ALVIN_RS01270	298274..300445	-	2172	WP_043795467.1	HAD-IIB family hydrolase	-
ALVIN_RS01275	300714..301130	+	417	WP_012969494.1	PaaI family thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-116)

Antitoxin

• SpoVT-AbrB domain (5-36)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15214.51 Da
• Isoelectric Point: 4.7721

>T24561 WP_012969489.1 NC_013851:c296194-295781 [Allochromatium vinosum DSM 180]
MSAAKVFFDTNILLYLLSEDVAKADRAEALLAAGGVISVQVLNEFASVASRKLRLSWPEIHEVLDTVRRLCRVEPLLLAT
HERGLEISEHYGFSIYDALIVASALSAKCEVLLTEDLQDGQRIDDRLLVRNPFGQTC

Nucleotide

• Length: 414 bp

>T24561 NC_013851:c296194-295781 [Allochromatium vinosum DSM 180]
ATGAGCGCGGCTAAGGTCTTTTTCGACACCAATATCCTGCTCTATCTGTTGTCGGAAGACGTAGCCAAGGCGGATCGCGC
CGAGGCGTTGTTGGCCGCCGGCGGTGTGATCAGCGTACAGGTGCTCAACGAATTCGCGTCCGTCGCGTCGCGGAAGCTGC
GTCTGTCCTGGCCGGAGATCCATGAGGTGCTGGATACGGTTCGCCGGCTGTGCCGAGTCGAACCGCTGCTGCTTGCCACC
CATGAGCGCGGTCTCGAGATCAGCGAGCACTACGGGTTTTCGATCTACGATGCCTTGATCGTCGCGTCCGCCTTGAGCGC
CAAGTGCGAGGTGCTGCTGACGGAAGACCTCCAGGACGGCCAGCGCATCGACGACAGGCTTTTGGTCAGGAATCCCTTTG
GTCAGACTTGTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8664.86 Da
• Isoelectric Point: 8.7580

>AT24561 WP_012969490.1 NC_013851:c296414-296181 [Allochromatium vinosum DSM 180]
MQVSRWGNSLAVRLPAAVVEALDLHEGDAIEIQVDSARALSIGKAPDNRALLERLRKYRGRLPEGFRFDRLEAHERG

Nucleotide

• Length: 234 bp

>AT24561 NC_013851:c296414-296181 [Allochromatium vinosum DSM 180]
ATGCAAGTGTCCAGATGGGGTAACAGTTTAGCGGTCCGCTTGCCGGCAGCCGTGGTCGAGGCGCTGGATCTGCATGAGGG
CGATGCGATCGAGATTCAGGTGGACAGTGCCCGCGCATTGAGTATCGGCAAGGCGCCTGACAACCGGGCGCTACTGGAGC
GGCTGCGCAAATACCGGGGCCGGTTGCCCGAGGGATTTCGTTTCGACCGTCTGGAGGCCCATGAGCGCGGCTAA

Structures

Toxin

• AlphaFold DB: D3RMF5

Antitoxin

• AlphaFold DB: D3RMF6