Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1143836..1144456 Replicon chromosome
Accession NZ_CP097572
Organism Enterobacter kobei strain C210239

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag M8978_RS05345 Protein ID WP_014882802.1
Coordinates 1143836..1144054 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag M8978_RS05350 Protein ID WP_008499288.1
Coordinates 1144082..1144456 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8978_RS05315 (M8978_05315) 1139845..1140105 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
M8978_RS05320 (M8978_05320) 1140108..1140248 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M8978_RS05325 (M8978_05325) 1140245..1140955 - 711 WP_045134726.1 GNAT family protein -
M8978_RS05330 (M8978_05330) 1141057..1142517 + 1461 WP_045134727.1 PLP-dependent aminotransferase family protein -
M8978_RS05335 (M8978_05335) 1142489..1142956 - 468 WP_014882800.1 YlaC family protein -
M8978_RS05340 (M8978_05340) 1143075..1143626 - 552 WP_014882801.1 maltose O-acetyltransferase -
M8978_RS05345 (M8978_05345) 1143836..1144054 - 219 WP_014882802.1 HHA domain-containing protein Toxin
M8978_RS05350 (M8978_05350) 1144082..1144456 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
M8978_RS05355 (M8978_05355) 1144968..1148114 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit AcrB -
M8978_RS05360 (M8978_05360) 1148137..1149330 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T245603 WP_014882802.1 NZ_CP097572:c1144054-1143836 [Enterobacter kobei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT245603 WP_008499288.1 NZ_CP097572:c1144456-1144082 [Enterobacter kobei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References