Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2148290..2148804 Replicon chromosome
Accession NZ_CP097571
Organism Staphylococcus aureus strain V40

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag M8789_RS10635 Protein ID WP_000581792.1
Coordinates 2148290..2148499 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag M8789_RS10640 Protein ID WP_000138934.1
Coordinates 2148511..2148804 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8789_RS10615 (2143798) 2143798..2145156 - 1359 WP_000611474.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M8789_RS10620 (2145171) 2145171..2146241 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
M8789_RS10625 (2146559) 2146559..2147761 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
M8789_RS10630 (2148025) 2148025..2148162 - 138 WP_000828354.1 Lmo0850 family protein -
M8789_RS10635 (2148290) 2148290..2148499 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
M8789_RS10640 (2148511) 2148511..2148804 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
M8789_RS10645 (2148970) 2148970..2150454 + 1485 WP_000571557.1 cardiolipin synthase -
M8789_RS10650 (2150482) 2150482..2151129 + 648 WP_001187631.1 HD domain-containing protein -
M8789_RS10655 (2151895) 2151895..2152767 - 873 WP_000725802.1 membrane protein insertase YidC -
M8789_RS10660 (2152853) 2152853..2153494 - 642 WP_000483148.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T245596 WP_000581792.1 NZ_CP097571:c2148499-2148290 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT245596 WP_000138934.1 NZ_CP097571:c2148804-2148511 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References