Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2128545..2129074 Replicon chromosome
Accession NZ_CP097571
Organism Staphylococcus aureus strain V40

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M8789_RS10545 Protein ID WP_000621175.1
Coordinates 2128545..2128907 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag M8789_RS10550 Protein ID WP_000948331.1
Coordinates 2128904..2129074 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8789_RS10525 (2125523) 2125523..2126293 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
M8789_RS10530 (2126268) 2126268..2126747 - 480 WP_001190825.1 anti-sigma B factor RsbW -
M8789_RS10535 (2126749) 2126749..2127075 - 327 WP_001052491.1 anti-sigma factor antagonist -
M8789_RS10540 (2127194) 2127194..2128195 - 1002 WP_250164304.1 PP2C family protein-serine/threonine phosphatase -
M8789_RS10545 (2128545) 2128545..2128907 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8789_RS10550 (2128904) 2128904..2129074 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
M8789_RS10555 (2129159) 2129159..2130307 - 1149 WP_001281160.1 alanine racemase -
M8789_RS10560 (2130373) 2130373..2130732 - 360 WP_000581198.1 holo-ACP synthase -
M8789_RS10565 (2130736) 2130736..2131227 - 492 WP_001205919.1 PH domain-containing protein -
M8789_RS10570 (2131214) 2131214..2132797 - 1584 WP_001294651.1 PH domain-containing protein -
M8789_RS10575 (2132790) 2132790..2133269 - 480 WP_001287083.1 hypothetical protein -
M8789_RS10580 (2133478) 2133478..2134038 - 561 WP_001092403.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T245595 WP_000621175.1 NZ_CP097571:c2128907-2128545 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT245595 WP_000948331.1 NZ_CP097571:c2129074-2128904 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References